TB drugs Flashcards by Ashley Brauchler | Brainscape

Q

MOI for isoniazid

A

inhibits cell wall synthesis (bactericidal)

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Q

How is isoniazid metabolized

A

by acetylation

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Q

Isoniazid adverse reactions

A

hepatotoxic, neuritis

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Q

MOI for rifampin

A

inhibits RNA polymerase

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Q

What bacteria does rifampin treat?

A

gram +/-, anerobes, atypical

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Q

How is rifampin metabolized?

A

hepatobiliary excretion

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Q

Adverse reactions of rifampin

A

liver impairment, orange urine/secretions, inducer

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Q

MOI of ethambutal

A

inhibits cell wall synthesis (cidal/static)

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Q

When is ethambutol used?

A

induction phase of TB

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Q

How is ethambutol metabolized?

A

renal, fecal excretion

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Q

Ethambutol adverse reactions

A

optic neuritis (avoid in children), rash

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Q

MOI for pyrazinimide

A

uncertain, intracellular

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Q

When is pyrazinamide used?

A

induction phase

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Q

How is pyrazinimide metabolized?

A

hepatic

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Q

Adverse reactions to pyrazinamide

A

hepatotoxicity, hyperuricemia

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