TB Flashcards
Isoniazid adverse effects
Peripheral neuritis, restlessness,muscle twitxhing,insomia
Rifampicin adverse effects
flu-like symptoms nd anemia
Rifampicin side effect
Red/orange stool or urine
Inhibits arabinosyl transferase in synthesis of arabinogalactan
Ethambutol
Ethambutol resistance occurs rapidly via mutations i
emb gene
Averse effect: dec visual acuity
Ethambutol
Pyrazynamide resistance
g
Binds to 30s ribosomal subunit and interfere with chon synthesis
streptomycib
Adverse effect: auditory and vestibular disturbances
Stre
First phase to target actively dividing cells
intensive phas
New case of Tb trearment regimen
2HRZE/2HR
Retreatment
2HRZES+1HRZE
5HRE
Drug dosages
INH
If px with neg dssm misses treatment for less than 1month
Continue tx and prolong to compensate
Px with positive dssm misses tx for more than a mont but less than 2 months
b