TB

Question 1

What is the role of Alveolar Macrophages in TB infections?

Answer 1

Mtb is transmitted through aerols, in the lungs the mycobacteria is taken up by macrophages and survives there by preventing the fusion of phagocytoes and lysosomes

Question 2

How are granulomas formed?

Answer 2

Receptors on the macrophage membrane interact with sugar residues on the bacterial surface (mannose-receptors) or complement receptors. The proliferation of mycobacteria attracts more phagosomes and T cells which fuse to great giant cells. This forms thick cell layers around the infection resulting in leisures