TASK 3 - CEREBELLUM Flashcards

1
Q

cerebellum

A
  • located in hindbrain
  • metencephalon (cerebellum + pons)
  • played critical role in development of cortical/ cognitive functions
  • allows info input into and out of cerebellum
  • -> input via brainstem into cerebellum
  • -> output via pons out of cerebellum –> into cortex
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2
Q

structural divisions

A
  • laminated cerebellar cortex on surface

- cerebellar deep nuclei deep in white matter

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3
Q

structural divisions

- lobes

A
  • anterior lobe: somatosensory info
  • posterior lobe: output to cortex
  • flocculonodular lobe: oldest cerebellar structure
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4
Q

structural divisions

- vermis + hemispheres

A
  • vermis: runs along midline of cerebellum, separates 2 hemispheres
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5
Q

functional divisions

1. cerebrocerebellum

A

= lateral hemispheres

  • receives input from the CEREBRUM
  • planning, initiation of movement + sensory feedback of motor movements
  • coordination of voluntary movements
  • cognitive, emotional control
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6
Q

functional divisions

2. spinocerebellum

A

= vermis

  • input from SPINAL cord
  • visual + auditory signals (relayed in brainstem nuclei)
  • regulates body + limb movements and muscle tone
  • compares info from where body stand and where it should be –> if discrepancy: corrects error signal
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7
Q

functional divisions

3. vestibulocerebellum

A

= floculonodular/flocular lobe

  • input from VESTIBULAR complex
  • regulates balance, posture, eye movements
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8
Q

pathways

A
  1. via cerebellar peduncles

2. via deep cerebellar nuclei

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9
Q

pathways

1. cerebellar peduncles

A

= white matter connections

  • connections between the cerebellum and other parts of the nervous system
  • contain fine branching nerve fibres
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10
Q
  1. cerebellar peduncles

a) superior

A

= largest output structure/ almost entirely efferent pathway

  • origin: deep cerebellar nuclei neurones –> to upper motor neurones in deep layers of superior colliculus –> delay in dorsal thalamus –> primary motor, premotor areas of cortex
  • limbic movements
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11
Q
  1. cerebellar peduncles

b) middle

A

= biggest peduncle; afferent pathway to cerebellum; descending

  • origin: pontine nuclei (neurones in the base of the contralateral pons) –> receives input from many sources (almost all cortical areas and superior colliculus) –> axons (transverse pontine fibres) cross midline and enter cerebellum via middle cerebellar peduncle
  • regulates info from proprioception (orient body in space) + regulates other sensory functioning
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12
Q
  1. cerebellar peduncles

c) inferior

A

= smallest but most complex peduncle

  • contains afferent + efferent pathways
    1) afferent ascending = axons from vestibular nuclei, spinal cord and brainstem tegmentum (inferior olive)
    2) efferent = axons project to vestibular nuclei and reticular formation
  • proprioceptive info (how different body parts relate to one another
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13
Q

pathways

2. deep cerebellar nuclei

A

= in each cerebellar hemisphere there are 4 major deep nuclei

  • each receiving input from different parts of cerebellum
    a) fastigal nuclei
    b) interposed nuclei (x2)
    c) dentate nuclei
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14
Q

input

A
  • major destination of input: cerebrocerebellum
    1. top-down/descending: cerebral cortex via pons
    2. bottom-up/ascending: from vestibular inputs, inferior olive, spinal cord
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15
Q

input

1. descending

A

= cerebral cortex via pons

  1. axons synapse on ipsilateral neurones in pontine nuclei
  2. pontine nuclei give rise to transverse projections that cross midline (form middle cerebellar peduncle) –> relays cortical signals to contralateral cerebellar hemisphere
    - signals derived from one cerebral hemisphere are processed by the neural circuits in the opposite cerebellar hemisphere
    - majority arises from primary and pre-motor cortices (frontal), primary and secondary somatic sensory cortices (anterior parietal) and higher order visual regions (posterior parietal)
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16
Q

input

2. ascending

A

= from vestibular inputs, inferior olive, spinal cord

  • vestibular and spinal inputs: remain ipsilateral from point of entry in brainstem (travelling inferior cerebellar peduncle)
  • -> right half of cerebellum is concerned with right part of the body
17
Q

output

1. ascending

A

a) cerebrocerebellar pathway = to pre-motor + associational cortices of frontal lobe –> motor planning
- feedback loop: collaterals to parvocellular red nucleus in midbrain –> inferior olives
- closed loops: to non-motor areas of the cortex from which signals originated (–> coordination of non-motor programs)
- open loops: input from multiple areas, output to motor cortices
- -> run in parallel
b) spinocerebellar pathways = to upper motor neurones –> execution of movement
- laterally positioned interposed nuclei –> via superior peduncle –> thalamus and frontal lobes

18
Q

output

2. descending

A

a) spinocerebellar pathways = directed to upper motor neurones responsible for execution of movement
- fastigial nuclei (vermis) –> inferior peduncle –> reticular formation + vestibular complex –> give rise to tracts governing axial + proximal limb muscles
b) vestibulocerebellar pathway - inferior peduncle –> vestibular complex that governs movement of eyes, head, neck, compensating for linear + rotational accelerations of the head

19
Q

cellular organisation

- layers

A
  1. molecular layer
    - apical dendrites of Golgi cells
  2. Purkinje cell layer
    - contains Purkinje cell bodies
  3. granule cell layer
    - contains granule cell bodies
20
Q

cellular organisation

- Purkinje cells

A

= ultimate destination of afferent pathways

  • input from cerebral cortex to Purkinje cells is indirect
  • huge dendrites that branch out –> receive input from heaps of parallel fibres
  • inhibitory (GABAergic)
  • projections to deep cerebellar nuclei that serve to shape discharge patterns
21
Q

cellular organisation

- mossy fibres

A

= indirect input

  • come from all sorts of sources (cortex, brainstem, spinal cord)
  • synapse on deep cerebellar nuclei + granule cells
  • -> granule cells give rise to parallel fibres –> synapse on Purkinje cells
22
Q

cellular organisation

- climbing fibres

A

= direct input

- inferior olive –> climbing fibres –> Purkinje cell + deep nuclei

23
Q

cellular organisation

- local circuit neurones

A

= modulate inhibitory output of Purkinje cells by inhibiting them after excitatory input from parallel fibres

  1. basket cells: lateral inhibition that may focus spatial distribution of Purkinje cell activity
  2. stellate cells
24
Q

cellular organisation

- Golgi cells

A

= receive input from parallel fibres and then inhibit those exact cells

25
Q

long-term depression

A

= sensorimotor synapses become less effective due to activation of climbing fibres and parallel fibres at same spot on Purkinje cells

26
Q

mechanisms of LTD

A
  1. climbing fibre activates Purkinje cell
  2. Ca2+ influx –> strong depolarisation of Purkinje cell
  3. depolarisation mediates/ makes Na+ influx from parallel fibres possible
  4. due to strong depolarisation metabotropic glutamate receptors allow influx of PKC
27
Q

functions

A
  • coordination
  • fine tuning (timing)
  • unconscious planning of motor behaviour
  • learning of motor behaviour
  • non-motor behaviour
28
Q

functions

- learning

A
  • feedback and error mechanisms
    a) implicit learning/ procedural memory:
  • learn event sequences
  • once learned motor plan, have template of movement in cerebellum
    b) associative learning
  • random coupling of two stimuli to form association
29
Q

functions

- cognition

A
  • speech production/perception

- emotion processing

30
Q

cerebellar dysfunction

A
  • ataxia: caused by lesions anywhere in fronto-pontine-cerebello-thalamo-cortical loop
  • nystagmus = eye fluctuations
  • truncal ataxia = inability to stand/sit upright
  • gait ataxia = drunken sailor walk
  • dysmetria = related to hand movements
  • dysdiadochokinesia = difficulty performing rapid alternating movements
  • tremor
  • slurred, imprecise speech
31
Q

forward model

A
  • cerebellum compares motor signals + sensory input
  • is important for prediction + sensorimotor learning
  • error signalling