tas Flashcards
where is leptin produced
adipocytes
rituximab
binds CD20 on surface of B cells
montelukast
blocks leukotriene D4 in lungs
vigabatrin
inhibits breakdown of GABA
where is somatostatin produced
hypothalmus and delta cells of GI tract
where is gherlin produced
fundus of stomach
Acute severe asthma attack
PEF 33-50% predicted
RR > 25
HR >110
inability to complete sentence in one breath
life threatning asthma
o2 sat < 92 partial pressure of oxygen< 8 normal CO2 altered conscious level cyanosis arrythmia hypotension poor respiratory effort silent chest PEF < 33%
Omalizumab
inhibits IgE
Adlimumab and infliximab
inhibit TNF
alemtuzumab
target CD52 on B and T cells
Gemtuzumab
targets CD 33 in leukemia
Glycogen storage disease Type 1
glucose-6-phosphatase deficiency
hypoglycemia,hepatomegally,lactic acidosis, growth failure
blinatumomab
targets CD 19 for refractory b cell leukemia
Medications that prolong QT
clarithromycin
fluoroquinolones
antimalarials
antifungals(ketoconazole)
CSF drainage
produced by choroid plexus –>lateral ventricle–> foramen of monroe–>third ventricle–> aqueduct of sylvus–>fourth ventricle–>subarachnoid space–> reabsorbed by arachnoid villi in supperior sagital sinus
Leukemia poor prognosis
- philedelphia (ch 9 and 22) NOT present
- additioal copy of chromosome 8
- hypodiploidy
- missing copy of chromosome 7
- translocation of chromosome 4 and 11
lamotrogine
can be used in pregnancy
inactivates sodium channels
ethosuximide
inhibits T-cell calcium channels in thalmic neurons
Metformin
decreased gluconeogenesis and increase peripheral utilization of glucose
cirullinemia
autosomal recessive urea cycle defect
accumulation of ammonia and citrulline in the blood
deficiency of arginosuccinate synthase
circle of willis
anterior cerebral artery posterior cerebral anterior communicating posterior communicating internal carotid
respiridone
antipsychotic , used with agression
antogonist: D2,5HT,histamine 1, alpha 1
How many stages of sleep?
5 stages
first 4 are N-REM (parasympathetic activity causing decrease in heart rate,bp and muscle tone) REM is the final stage (heart rate,bp,RR,temp increase)
