tas

Question 1

where is leptin produced

Answer 1

adipocytes

Question 2

rituximab

Answer 2

binds CD20 on surface of B cells

Question 3

montelukast

Answer 3

blocks leukotriene D4 in lungs

Question 4

vigabatrin

Answer 4

inhibits breakdown of GABA

Question 5

where is somatostatin produced

Answer 5

hypothalmus and delta cells of GI tract

Question 6

where is gherlin produced

Answer 6

fundus of stomach

Question 7

Acute severe asthma attack

Answer 7

PEF 33-50% predicted
RR > 25
HR >110
inability to complete sentence in one breath

Question 8

life threatning asthma

Answer 8

o2 sat < 92 
partial pressure of oxygen< 8 
normal CO2
altered conscious level
cyanosis 
arrythmia 
hypotension 
poor respiratory effort 
silent chest
PEF < 33%

Question 9

Omalizumab

Answer 9

inhibits IgE

Question 10

Adlimumab and infliximab

Answer 10

inhibit TNF

Question 11

alemtuzumab

Answer 11

target CD52 on B and T cells

Question 12

Gemtuzumab

Answer 12

targets CD 33 in leukemia

Question 13

Glycogen storage disease Type 1

Answer 13

glucose-6-phosphatase deficiency

hypoglycemia,hepatomegally,lactic acidosis, growth failure

Question 14

blinatumomab

Answer 14

targets CD 19 for refractory b cell leukemia

Question 15

Medications that prolong QT

Answer 15

clarithromycin
fluoroquinolones
antimalarials
antifungals(ketoconazole)

Question 16

CSF drainage

Answer 16

produced by choroid plexus –>lateral ventricle–> foramen of monroe–>third ventricle–> aqueduct of sylvus–>fourth ventricle–>subarachnoid space–> reabsorbed by arachnoid villi in supperior sagital sinus

Question 17

Leukemia poor prognosis

Answer 17

• philedelphia (ch 9 and 22) NOT present
• additioal copy of chromosome 8
• hypodiploidy
• missing copy of chromosome 7
• translocation of chromosome 4 and 11

Question 18

lamotrogine

Answer 18

can be used in pregnancy

inactivates sodium channels

Question 19

ethosuximide

Answer 19

inhibits T-cell calcium channels in thalmic neurons

Question 20

Metformin

Answer 20

decreased gluconeogenesis and increase peripheral utilization of glucose

Question 21

cirullinemia

Answer 21

autosomal recessive urea cycle defect
accumulation of ammonia and citrulline in the blood
deficiency of arginosuccinate synthase

Question 22

circle of willis

Answer 22

anterior cerebral artery 
posterior cerebral 
anterior communicating 
posterior communicating 
internal carotid

Question 23

respiridone

Answer 23

antipsychotic , used with agression

antogonist: D2,5HT,histamine 1, alpha 1

Question 24

How many stages of sleep?

Answer 24

5 stages
first 4 are N-REM (parasympathetic activity causing decrease in heart rate,bp and muscle tone) REM is the final stage (heart rate,bp,RR,temp increase)