targeted radionuclide therapy peptide receptor radionuclide therapy microsphers

Question 1

3 targeted therpies for prostate cx

Answer 1

1-samarium 153 (quadramet)
2-strontium-89 (metastron)
3-radium-223 (xofigo)

Question 2

which therpay is used for palliative care for bnoe pain due to prtosate metsq

Answer 2

sm 153 and sr 89

Question 3

which therpay treats castrate resistant prsoate cx that has mets bone

Answer 3

ra 223

Question 4

when is sm 153 not okay

Answer 4

danger of spinal cord compression or pathlogic fx in extremities expected (instead surgery or local XRT)

Question 5

energy and half life of sm 153

Answer 5

beta=0.81 Mev gamma= 103 keV and 1.9 d

Question 6

energy and half life of sr 89

Answer 6

beta 1.46 Mev and 50.5 days

Question 7

sm153 dose

Answer 7

1 mCi/kg

Question 8

sr 89 dose

Answer 8

40-60 uCi/kg

Question 9

targeting mech or sm153

Answer 9

tetraphosphonate

Question 10

targeting mech of sr 89

Answer 10

calcium analog

Question 11

sm153 tissue penetration and sr 89

Answer 11

sm153= 0.60 mm and sr89= 2.44 mm

Question 12

does a pure beta emitter need assaying prior to admin

Answer 12

nocan

Question 13

can sm 153 edtmp be imaged

Answer 13

yes bc gamma

Question 14

xofigo dose is

Answer 14

1.35 uCi/kgo

Question 15

how is xofigo given

Answer 15

6 inj over 4 week intervals