target selection and validation

Question 1

describe the drug discovery and development life cycle

Question 2

describe the challenges of the drug discovery and development life cycle

Question 3

techniques for target identification + specific disease context

Question 4

discuss important principles of target validation

Question 5

discuss important principles of target validation

Question 6

experiment to validate novel drug target using appropriate methodologies

Answer 6

r

Question 7

why do drugs fail at clinical trials?

Answer 7

problems associated with molecule, target, DA exit, or behind in class. lack of efficiency, poor safety, company strategy or market reasons

Question 8

types of new drugs

Answer 8

first in class, new generation of drugs currently in use, me-too, best in class

Question 9

what is a best in class drug

Answer 9

therapeutic superiority and improved treatment compliance without compromising safety and quality of life, improved safety profile with similar efficiency to first in class

Question 10

philosophies of drug discovery

Answer 10

target based vs phenotypic based (target agnostic)

Question 11

potential drug targets?

Answer 11

receptors, ion channels, hormones and factors, nucleic acids, enzymes, nuclear receptors

Question 12

what are the approaches in target based drug discovery

Answer 12

molecular approach (intercellular targets, regulatory structure and metabolic patterns), systems approach (phenotype), genomic approach (diseased to normal)

Question 13

molecular basis of diseases discussed

Answer 13

CML