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Robbins Pathology Heme/Lymph (Chapters 13,14) > Table 13-6: Lymphomas And Leukemias > Flashcards

Table 13-6: Lymphomas And Leukemias Flashcards

1
Q

What condition has the genotype of:

-t(11;14) CyclinD1-IgH fusion

A

Mantle cell lymphoma

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2
Q

Which condition has salient clinical features of:

  • Older adults
  • Present with lymphadenopathy
  • Agressive
A

Peripheral T cell lymphoma

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3
Q

Which condition has the genotype of NOTCH1

A

T-cell acute lymphoblastic leukemia/lymphoma (ALL)

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4
Q

What condition has the salient clinical features of:

  • Children and hound adults
  • LN and ST diseases
  • agressive
A

Anaplastic large cell lymphoma

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5
Q

What is the cell of origin for small lymphocytic lymphoma/chronic lymphocytic leukemia

A

-Naive B cell or memory B cell

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6
Q

What condition has the genotype of:

-EBV associated, no chromosomal abnormalities

A

Extranodal NK/T cell lymphoma

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7
Q

Which condition has the genotype of:

  • MYC and Ig loci translocation
  • t(8;14)
  • Some EBV associated
A

Burkitt lymphoma

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8
Q

T-cell acute lymphoblastic leukemia/lymphoma (ALL) is which cell of origin

A

-Precursor T cell

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9
Q

What condition has the salient clinical features of:

  • older males with disseminated disease
  • moderately aggressive
A

-mantle cell lymphoma

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10
Q

What condition has the genotype of:

-HTLV-1 provirus

A

Adult T cell leukemia/lymphoma

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11
Q

What is the cell of origin for B-cell acute lymphoblastic leukemia/lymphoma (ALL)

A

Bone marrow precursor B cell

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12
Q

What condition as the genotype of:

-ALK

A

Anaplastic large cell lymphoma

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13
Q

What is the condition with the genotype:

-t(14;18)- BCL2-IgH fusion gene

A

Follicular lymphoma

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14
Q

What is the cell of origin in Burkitt lymphoma

A

Germinal center B cell

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15
Q

Which condition has the salient clinical feature of:

  • Arises in Extranodal sites
  • In adults with chronic inflammatory disease
  • may remain localized
A

Extranodal marginal zone lymphoma

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16
Q

What is the cell of origin for Multiple myeloma/solitary plasmacytoma

A

Post germinal center bone barrow homing plasma cell

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17
Q

Which condition has the salient clinical features of:

  • all ages, but most common in adults
  • appears as a fast growing mass
  • 30% Extranodal and aggressive
A

Diffuse large B cell lymphoma

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18
Q

Which condition has the salient clinical features of:

  • Adolescents or younger adults with extra-nodal mass
  • Uncommonly presents as “leukemia”
  • Agressive
A

Burkitt lymphoma

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19
Q

Which condition has the salient clinical features of:

  • Adults with cutaneous lesions
  • marrow involvement
  • hypercalcemia
  • Mainly in Japan, West africa, Caribbean
  • Agressive
A

Adult T cell leukemia/lymphoma

20
Q

What is the cell of origin for anaplastic large cell lymphoma

A

Cytotoxic T cell

21
Q

What condition has the genotype of:

  • t(12;21)
  • RUNX1
  • ETV6
A

B-cell acute lymphoblastic leukemia/lymphoma (ALL)

22
Q

Which condition has the genotype of:

  • BCL6 (30%)
  • BCL2 (10%)
  • MYC (5%)
A

Diffuse large B cell lymphoma

23
Q

What condition has the genotype of BRAF

A

Hairy cell leukemia

24
Q

What is the cell of origin for adult T cell leukemia/lymphoma

A

Helper T cell

25
What is the cell origin for hair cell leukemia
Memory B cells
26
What is the cell of origin for follicular lymphoma
Germinal center B cell
27
What is the cell of origin for Extranodal NK/T cell lymphoma
NK cell (common) or T cell (rare)
28
What condition has the genotype of: | STAT3
Large granular lymphocytic leukemia
29
What condition has the genotype of: - Trisomy 12 - Deletions of 11q, 13q, and 17p
Small lymphocytic lymphoma/chronic lymphocytic leukemia
30
What is the cell of origin in large granular lymphocytic leukemia
Two types: Cytotoxic T cell and NK cells
31
What condition has the genotype of: - t(11;18)-MALT1-IAP2 - t(1;14)- BCL10-IgH - t(14;18)-MALT1-IgH
Extranodal marginal zone lymphoma
32
What condition shows the clinical salient clinical features of: - Predominantly children - symptoms with marrow depletion - aggressive
B-cell acute lymphoblastic leukemia/lymphoma (ALL)
33
What is the cell origin for mantle cell lymphoma
Naive B cell
34
Which condition has the salient clinical features of: | -Adults with splenomegaly, neutropenia, anemia, with occasional autoimmune conditons
Large granular lymphocytic leukemia
35
What is the condition with salient clinical features: - older adults - generalized lymphadenopathy and marrow involvement - indolent
Follicular lymphoma
36
What is the cell of origin for peripheral T cell lymphoma
Helper or cytotoxic T cell
37
Which condition has the salient clinical features of: - Predominantly adolescent males - thymic masses and variable bone involvement - agressive
T-cell acute lymphoblastic leukemia/lymphoma (ALL)
38
What is the cell of origin for diffuse large B cell lymphoma
Germinal center or post germinal center B cell
39
Which condition has the salient clinical features of: - Adults - destructive Extranodal masses - Most common is the sinonasal - Aggressive
Extranodal NK/T cell lymphoma
40
What is the cell of origin for Extranodal marginal zone lymphoma
Memory B cell
41
Which is the cell of origin for mycosis/Sezary syndrome
-Helper T cell
42
Which condition has the salient clinical features of: | -Older males with pancytopenia and splenomegaly
Hairy cell leukemia
43
Which condition has the genotype of: - IgH rearrangements - 13q deletions
Multiple myeloma/solitary plasmacytoma
44
Which conditions has the salient clinical features of: | -older males with lyric bone disease lesions with fractures, hypercalcemia, Renal failure
Multiple myeloma/solitary plasmacytoma
45
What condition has the salient clinical feature of: - Older adults with bone marrow, LN, spleen, and liver disease - autoimmune hemolysis
Small lymphocytic lymphoma/chronic lymphocytic leukemia

Robbins Pathology Heme/Lymph (Chapters 13,14) (4 decks)

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