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Robbins Pathology Heme/Lymph (Chapters 13,14) > Table 13-6: Lymphomas And Leukemias > Flashcards

Table 13-6: Lymphomas And Leukemias Flashcards

1
Q

What condition has the genotype of:

-t(11;14) CyclinD1-IgH fusion

A

Mantle cell lymphoma

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2
Q

Which condition has salient clinical features of:

  • Older adults
  • Present with lymphadenopathy
  • Agressive
A

Peripheral T cell lymphoma

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3
Q

Which condition has the genotype of NOTCH1

A

T-cell acute lymphoblastic leukemia/lymphoma (ALL)

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4
Q

What condition has the salient clinical features of:

  • Children and hound adults
  • LN and ST diseases
  • agressive
A

Anaplastic large cell lymphoma

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5
Q

What is the cell of origin for small lymphocytic lymphoma/chronic lymphocytic leukemia

A

-Naive B cell or memory B cell

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6
Q

What condition has the genotype of:

-EBV associated, no chromosomal abnormalities

A

Extranodal NK/T cell lymphoma

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7
Q

Which condition has the genotype of:

  • MYC and Ig loci translocation
  • t(8;14)
  • Some EBV associated
A

Burkitt lymphoma

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8
Q

T-cell acute lymphoblastic leukemia/lymphoma (ALL) is which cell of origin

A

-Precursor T cell

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9
Q

What condition has the salient clinical features of:

  • older males with disseminated disease
  • moderately aggressive
A

-mantle cell lymphoma

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10
Q

What condition has the genotype of:

-HTLV-1 provirus

A

Adult T cell leukemia/lymphoma

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11
Q

What is the cell of origin for B-cell acute lymphoblastic leukemia/lymphoma (ALL)

A

Bone marrow precursor B cell

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12
Q

What condition as the genotype of:

-ALK

A

Anaplastic large cell lymphoma

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13
Q

What is the condition with the genotype:

-t(14;18)- BCL2-IgH fusion gene

A

Follicular lymphoma

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14
Q

What is the cell of origin in Burkitt lymphoma

A

Germinal center B cell

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15
Q

Which condition has the salient clinical feature of:

  • Arises in Extranodal sites
  • In adults with chronic inflammatory disease
  • may remain localized
A

Extranodal marginal zone lymphoma

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16
Q

What is the cell of origin for Multiple myeloma/solitary plasmacytoma

A

Post germinal center bone barrow homing plasma cell

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17
Q

Which condition has the salient clinical features of:

  • all ages, but most common in adults
  • appears as a fast growing mass
  • 30% Extranodal and aggressive
A

Diffuse large B cell lymphoma

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18
Q

Which condition has the salient clinical features of:

  • Adolescents or younger adults with extra-nodal mass
  • Uncommonly presents as “leukemia”
  • Agressive
A

Burkitt lymphoma

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19
Q

Which condition has the salient clinical features of:

  • Adults with cutaneous lesions
  • marrow involvement
  • hypercalcemia
  • Mainly in Japan, West africa, Caribbean
  • Agressive
A

Adult T cell leukemia/lymphoma

20
Q

What is the cell of origin for anaplastic large cell lymphoma

A

Cytotoxic T cell

21
Q

What condition has the genotype of:

  • t(12;21)
  • RUNX1
  • ETV6
A

B-cell acute lymphoblastic leukemia/lymphoma (ALL)

22
Q

Which condition has the genotype of:

  • BCL6 (30%)
  • BCL2 (10%)
  • MYC (5%)
A

Diffuse large B cell lymphoma

23
Q

What condition has the genotype of BRAF

A

Hairy cell leukemia

24
Q

What is the cell of origin for adult T cell leukemia/lymphoma

A

Helper T cell

25
Q

What is the cell origin for hair cell leukemia

A

Memory B cells

26
Q

What is the cell of origin for follicular lymphoma

A

Germinal center B cell

27
Q

What is the cell of origin for Extranodal NK/T cell lymphoma

A

NK cell (common) or T cell (rare)

28
Q

What condition has the genotype of:

STAT3

A

Large granular lymphocytic leukemia

29
Q

What condition has the genotype of:

  • Trisomy 12
  • Deletions of 11q, 13q, and 17p
A

Small lymphocytic lymphoma/chronic lymphocytic leukemia

30
Q

What is the cell of origin in large granular lymphocytic leukemia

A

Two types: Cytotoxic T cell and NK cells

31
Q

What condition has the genotype of:

  • t(11;18)-MALT1-IAP2
  • t(1;14)- BCL10-IgH
  • t(14;18)-MALT1-IgH
A

Extranodal marginal zone lymphoma

32
Q

What condition shows the clinical salient clinical features of:

  • Predominantly children
  • symptoms with marrow depletion
  • aggressive
A

B-cell acute lymphoblastic leukemia/lymphoma (ALL)

33
Q

What is the cell origin for mantle cell lymphoma

A

Naive B cell

34
Q

Which condition has the salient clinical features of:

-Adults with splenomegaly, neutropenia, anemia, with occasional autoimmune conditons

A

Large granular lymphocytic leukemia

35
Q

What is the condition with salient clinical features:

  • older adults
  • generalized lymphadenopathy and marrow involvement
  • indolent
A

Follicular lymphoma

36
Q

What is the cell of origin for peripheral T cell lymphoma

A

Helper or cytotoxic T cell

37
Q

Which condition has the salient clinical features of:

  • Predominantly adolescent males
  • thymic masses and variable bone involvement
  • agressive
A

T-cell acute lymphoblastic leukemia/lymphoma (ALL)

38
Q

What is the cell of origin for diffuse large B cell lymphoma

A

Germinal center or post germinal center B cell

39
Q

Which condition has the salient clinical features of:

  • Adults
  • destructive Extranodal masses
  • Most common is the sinonasal
  • Aggressive
A

Extranodal NK/T cell lymphoma

40
Q

What is the cell of origin for Extranodal marginal zone lymphoma

A

Memory B cell

41
Q

Which is the cell of origin for mycosis/Sezary syndrome

A

-Helper T cell

42
Q

Which condition has the salient clinical features of:

-Older males with pancytopenia and splenomegaly

A

Hairy cell leukemia

43
Q

Which condition has the genotype of:

  • IgH rearrangements
  • 13q deletions
A

Multiple myeloma/solitary plasmacytoma

44
Q

Which conditions has the salient clinical features of:

-older males with lyric bone disease lesions with fractures, hypercalcemia, Renal failure

A

Multiple myeloma/solitary plasmacytoma

45
Q

What condition has the salient clinical feature of:

  • Older adults with bone marrow, LN, spleen, and liver disease
  • autoimmune hemolysis
A

Small lymphocytic lymphoma/chronic lymphocytic leukemia

Robbins Pathology Heme/Lymph (Chapters 13,14) (4 decks)

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