Table 13-6: Lymphomas And Leukemias Flashcards
What condition has the genotype of:
-t(11;14) CyclinD1-IgH fusion
Mantle cell lymphoma
Which condition has salient clinical features of:
- Older adults
- Present with lymphadenopathy
- Agressive
Peripheral T cell lymphoma
Which condition has the genotype of NOTCH1
T-cell acute lymphoblastic leukemia/lymphoma (ALL)
What condition has the salient clinical features of:
- Children and hound adults
- LN and ST diseases
- agressive
Anaplastic large cell lymphoma
What is the cell of origin for small lymphocytic lymphoma/chronic lymphocytic leukemia
-Naive B cell or memory B cell
What condition has the genotype of:
-EBV associated, no chromosomal abnormalities
Extranodal NK/T cell lymphoma
Which condition has the genotype of:
- MYC and Ig loci translocation
- t(8;14)
- Some EBV associated
Burkitt lymphoma
T-cell acute lymphoblastic leukemia/lymphoma (ALL) is which cell of origin
-Precursor T cell
What condition has the salient clinical features of:
- older males with disseminated disease
- moderately aggressive
-mantle cell lymphoma
What condition has the genotype of:
-HTLV-1 provirus
Adult T cell leukemia/lymphoma
What is the cell of origin for B-cell acute lymphoblastic leukemia/lymphoma (ALL)
Bone marrow precursor B cell
What condition as the genotype of:
-ALK
Anaplastic large cell lymphoma
What is the condition with the genotype:
-t(14;18)- BCL2-IgH fusion gene
Follicular lymphoma
What is the cell of origin in Burkitt lymphoma
Germinal center B cell
Which condition has the salient clinical feature of:
- Arises in Extranodal sites
- In adults with chronic inflammatory disease
- may remain localized
Extranodal marginal zone lymphoma
What is the cell of origin for Multiple myeloma/solitary plasmacytoma
Post germinal center bone barrow homing plasma cell
Which condition has the salient clinical features of:
- all ages, but most common in adults
- appears as a fast growing mass
- 30% Extranodal and aggressive
Diffuse large B cell lymphoma
Which condition has the salient clinical features of:
- Adolescents or younger adults with extra-nodal mass
- Uncommonly presents as “leukemia”
- Agressive
Burkitt lymphoma
Which condition has the salient clinical features of:
- Adults with cutaneous lesions
- marrow involvement
- hypercalcemia
- Mainly in Japan, West africa, Caribbean
- Agressive
Adult T cell leukemia/lymphoma
What is the cell of origin for anaplastic large cell lymphoma
Cytotoxic T cell
What condition has the genotype of:
- t(12;21)
- RUNX1
- ETV6
B-cell acute lymphoblastic leukemia/lymphoma (ALL)
Which condition has the genotype of:
- BCL6 (30%)
- BCL2 (10%)
- MYC (5%)
Diffuse large B cell lymphoma
What condition has the genotype of BRAF
Hairy cell leukemia
What is the cell of origin for adult T cell leukemia/lymphoma
Helper T cell
What is the cell origin for hair cell leukemia
Memory B cells
What is the cell of origin for follicular lymphoma
Germinal center B cell
What is the cell of origin for Extranodal NK/T cell lymphoma
NK cell (common) or T cell (rare)
What condition has the genotype of:
STAT3
Large granular lymphocytic leukemia
What condition has the genotype of:
- Trisomy 12
- Deletions of 11q, 13q, and 17p
Small lymphocytic lymphoma/chronic lymphocytic leukemia
What is the cell of origin in large granular lymphocytic leukemia
Two types: Cytotoxic T cell and NK cells
What condition has the genotype of:
- t(11;18)-MALT1-IAP2
- t(1;14)- BCL10-IgH
- t(14;18)-MALT1-IgH
Extranodal marginal zone lymphoma
What condition shows the clinical salient clinical features of:
- Predominantly children
- symptoms with marrow depletion
- aggressive
B-cell acute lymphoblastic leukemia/lymphoma (ALL)
What is the cell origin for mantle cell lymphoma
Naive B cell
Which condition has the salient clinical features of:
-Adults with splenomegaly, neutropenia, anemia, with occasional autoimmune conditons
Large granular lymphocytic leukemia
What is the condition with salient clinical features:
- older adults
- generalized lymphadenopathy and marrow involvement
- indolent
Follicular lymphoma
What is the cell of origin for peripheral T cell lymphoma
Helper or cytotoxic T cell
Which condition has the salient clinical features of:
- Predominantly adolescent males
- thymic masses and variable bone involvement
- agressive
T-cell acute lymphoblastic leukemia/lymphoma (ALL)
What is the cell of origin for diffuse large B cell lymphoma
Germinal center or post germinal center B cell
Which condition has the salient clinical features of:
- Adults
- destructive Extranodal masses
- Most common is the sinonasal
- Aggressive
Extranodal NK/T cell lymphoma
What is the cell of origin for Extranodal marginal zone lymphoma
Memory B cell
Which is the cell of origin for mycosis/Sezary syndrome
-Helper T cell
Which condition has the salient clinical features of:
-Older males with pancytopenia and splenomegaly
Hairy cell leukemia
Which condition has the genotype of:
- IgH rearrangements
- 13q deletions
Multiple myeloma/solitary plasmacytoma
Which conditions has the salient clinical features of:
-older males with lyric bone disease lesions with fractures, hypercalcemia, Renal failure
Multiple myeloma/solitary plasmacytoma
What condition has the salient clinical feature of:
- Older adults with bone marrow, LN, spleen, and liver disease
- autoimmune hemolysis
Small lymphocytic lymphoma/chronic lymphocytic leukemia
