T Cell Effector Molecules

Question 1

Interlekin-2 (IL-2) important function

*source

Answer 1

T cell growth

*source: TH1

Question 2

Interferon-gamma (INF-gamma) important functions

*source

Answer 2

• Activation of macrophages (MHC I and II upregulation)
• Isotype switching to IgG (IgG1 and IgG3)
• activates NK cells
• source: TH1, CTL

Question 3

Lymphotoxin (LT, TNF-beta) important function

*source

Answer 3

Activates macrophages inducing NO production

*source: TH1 and some CTL

Question 4

Interleukin-4 (IL-4) important functions

*source

Answer 4

Upregulates B cell:

• Activation
• Growth
• IgE production (and also IgG2 and IgG4)
• MHC II induction

T cell:
- signals for growth and survival

*source: TH2

Question 5

Interleukin-5 (IL-5) important functions

*source

Answer 5

B cells:
- differentiation IgA isotype (both subtypes)

Hematopoietic cells:
- upregulates eosinophil growth and differentiation

*source: TH2

Question 6

Interleukin-10 (IL-10) important functions

*source

Answer 6

T cells:
- inhibits TH1

Macrophages:
- Inhibits cytokine release

*source: TH2, Treg

Question 7

Interleukin-3 (IL-3) important function

*source

Answer 7

Hematopoietic cells:
- Growth factor for progenitor Hematopoietic cells (multi-CSF)]

*source: TH1, TH2 and some CTL

Question 8

Tumor necrosis factor-alpha (TNF-alpha) important funcions

*source

Answer 8

Macrophages:
- activates and induces NO production

Somatic cells:
- activates microvascular endothelium

*source: TH1, TH2, and some CTL

Question 9

Granulocytes-macrophage-colony-stimulating factor (GM-CSF) important function
*source

Answer 9

Hematopoietic cells:
- More production of granulocytes, macrophages, and dendritic cells

*source: TH1, TH2 and some CTL

Question 10

Transforming Growth factor-ß (TGF-ß) important functions

*source

Answer 10

B cells:

• Inhibits growth IgA switch factor
• inducing isotype swiching to IgG (IgG2 and IgG4)

T cells:
- Inhibits growth, promotes survival

Macrophages:
- inhibits activation

*source: CD4 T cells (Treg)

Question 11

Interleukin-17 (IL-17) important functions

*source

Answer 11

Hematopoietic cells:
- stimulates neutrophil recruitment

Somatic cells:
- stimulates fibroblasts and epithelial cells to secrete chemokines

*source: CD4 T cells (TH17)

Question 12

Interleukin-22 (IL-22) important functions

*source

Answer 12

Somatic cells:
-induces production of antimicrobial peptide by endothelial cells

*source: CD4 T cells (TH17)