T-cell differentiation

Question 1

Positive and negative selection

Answer 1

Thymus

Question 2

Positive selection

Answer 2

Thymic cortex

Question 3

Negative selection

Answer 3

Cortico-medullary junction

Question 4

Positive selection

Answer 4

T-cells expressing TCR capable of binding surface self MHC molecules survive

Question 5

Negative selection

Answer 5

T-cells expressing TCRs with high affinity for self antigens undergo apoptosis

Question 6

Helper T cells + IL-12

Answer 6

Th1 cells make IL-2, INF-gamma and activate macrophages and CD-8+ T-cells (CMI)

Question 7

Helper T-cells + IL-4

Answer 7

Th2 cells make IL-4, IL-5 and help B cells make antibodies IgE>IgG (Humoral response)