T cell Development and Effector Function Flashcards
1
Q
Where do TCRs undergo affinity maturation?
A
They don’t undergo affinity maturation.
2
Q
Where is CD3 ? What does it do?
A
Every T cell. Signal transduction
3
Q
Where does CD4 bind?
A
Binds MHC class II, but not on the peptide. TCR binds the MHC II:peptide
4
Q
What does CD28 bind and what does it do?
A
Binds B7-1/B7-2 on MHC II. Needed to activate T cell.
Binding causes release of IL-2
Expressed on Cd4+
5
Q
What does CTLA-4 bind and what does it do?
A
Binds B7-1/B7-2 on MHC II. Shuts down T cell and IL 2 production
6
Q
What does PD-1 bind and what does it do?
A
binds PD-L1/PD-L2 on MHC II. Shuts down T cell.
7
Q
What does LFA-1 bind and what does it do?
A
Binds ICAM-1. Helps stabilize
