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MSK > Systemic Rheum Diseases > Flashcards

Systemic Rheum Diseases Flashcards

1
Q

anti-cyclic citrullinated peptide (anti-CCP)

A

rheumatoid arthritis

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2
Q

anti-centromere

A

limited systemic sclerosis (CREST)

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3
Q

anti-Jo-1

A

polymyositis/dermatomyositis

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4
Q

anti-Scl70 (DNA topoisomerase)

A

diffuse systemic sclerosis

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5
Q

anti-RNA polymerase (anti-US RNP)

A

systemic sclerosis, esp with renal crisis

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6
Q

anti-Smith

A

lupus

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7
Q

anti-U1 RNp

A

mixed connective tissue disease

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8
Q

anti-dsDNA

A

lupus, esp with nephritis

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9
Q

anti-nuclear (ANA

A

lupus, may others

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10
Q

anti-SSA (anti-Ro)

A

Sjogren syndrome, neonatal lupus, subcutaneous lupus

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11
Q

anti-SSB (anti-La)

A

Sjogren syndrome, neonatal lupus, subcutaneous lupus

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12
Q

Anti-myeloperoxidase (P-ANCA)

A

microscopic polyangiitis, Churgg-Strauss

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13
Q

anti-proteinase-3 (C-ANCA)

A

granulomatosis with polyangiitis (Wegener’s)

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14
Q

Pulmonary disease in RA

A

Fibrosing interstitial lung disease → UPI > NSIP with abundant lymphocytes & germinal centers
+ rheumatoid nodules

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15
Q

Most common cause of secondary AA amyloidosis

A

RA

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16
Q

Pulmonary disease in systemic sclerosis

A

NSIP pattern

17
Q

Mediators of scleroderma lung

A

IL-8, TNF, MIF1alpha, RANTES, endothelin-1, TGF-beta

18
Q

Pulmonary disease in Sjogren Syndrome

A

Lymphoma

19
Q

Pulmonary disease in systemic sclerosis, limited form

A

Pulmonary artery hypertension

20
Q

HLA associated with RA

A

HLA-DR4 (B1) (MHC class II)

21
Q

HLA associated with ankylosing spondylitis

A

HLA-B27

22
Q

HLA associated with Sjogren’s

A

HLA-DR3

23
Q

Abs for DM

A

anti-Mi-2

24
Q

Abs for PM

A

anti-PM-Scl → with scleroderma-type presentation
anti-Jo-1 → mechanics hands, raynauds, antisynthetase syndrome, ILD
anti-SRP → severe

MSK (6 decks)

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