Systemic Rheum Diseases Flashcards
anti-cyclic citrullinated peptide (anti-CCP)
rheumatoid arthritis
anti-centromere
limited systemic sclerosis (CREST)
anti-Jo-1
polymyositis/dermatomyositis
anti-Scl70 (DNA topoisomerase)
diffuse systemic sclerosis
anti-RNA polymerase (anti-US RNP)
systemic sclerosis, esp with renal crisis
anti-Smith
lupus
anti-U1 RNp
mixed connective tissue disease
anti-dsDNA
lupus, esp with nephritis
anti-nuclear (ANA
lupus, may others
anti-SSA (anti-Ro)
Sjogren syndrome, neonatal lupus, subcutaneous lupus
anti-SSB (anti-La)
Sjogren syndrome, neonatal lupus, subcutaneous lupus
Anti-myeloperoxidase (P-ANCA)
microscopic polyangiitis, Churgg-Strauss
anti-proteinase-3 (C-ANCA)
granulomatosis with polyangiitis (Wegener’s)
Pulmonary disease in RA
Fibrosing interstitial lung disease → UPI > NSIP with abundant lymphocytes & germinal centers
+ rheumatoid nodules
Most common cause of secondary AA amyloidosis
RA
Pulmonary disease in systemic sclerosis
NSIP pattern
Mediators of scleroderma lung
IL-8, TNF, MIF1alpha, RANTES, endothelin-1, TGF-beta
Pulmonary disease in Sjogren Syndrome
Lymphoma
Pulmonary disease in systemic sclerosis, limited form
Pulmonary artery hypertension
HLA associated with RA
HLA-DR4 (B1) (MHC class II)
HLA associated with ankylosing spondylitis
HLA-B27
HLA associated with Sjogren’s
HLA-DR3
Abs for DM
anti-Mi-2
Abs for PM
anti-PM-Scl → with scleroderma-type presentation
anti-Jo-1 → mechanics hands, raynauds, antisynthetase syndrome, ILD
anti-SRP → severe
