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Pain > Systemic Lupus Erythematosus SLE > Flashcards

Systemic Lupus Erythematosus SLE Flashcards

1
Q

what is SLE

A

autoimmune attach on connective tissue

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2
Q

Drugs and supplements for SLE

A
  • NSAIDs
  • Glucocorticoids
  • csDMARDs: Hydroxychloroquine, Azathioprine, Cyclophosphamide
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3
Q

MOA of azathioprine

A

inhibit de novo purine synthesis (mainly in lymphocytes) via production of thioguanine metabolites

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4
Q

ADR of azathioprine

A
  • N&V
  • Myelosuppression
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5
Q

MOA of cyclophosphamide

A

DNA alkylation (lymphocytes and rapidly dividing cells especially sensitive)

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6
Q

ADR of cyclophosphamide

A
  • N&V
  • myelosuppression
  • infection
  • haemorrhagic cystitis
  • bladder cancer
  • alopecia (hair lost)
  • ovarian failure
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Pain (8 decks)

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