Systemic Lupus Erythematosus Flashcards
What is the classic demographic who gets SLE?
Women of child bearing age (15-35 years old), african american
What are the 4 ‘skin’ criteria for SLE diagnosis?
Malar rash, photosensitivity, oral/nasal ulcers, or discoid rash
What is the ‘RASH’ criteria for SLE diagnosis?
Renal
Arthritis
Serositis (pleuritis and pericarditis)
Hematologic cytopenias/hemolytic anemia
What is the ‘NIA’ criteria for SLE diagnosis?
Neurological
Immunological
ANA antibodies
What are two antibodies present in SLE? Which is sensitive but not specific, and which is highly specific?
ANA present is sensitive but not specific. Anti-dsDNA is highly specific for SLE
What are 4 key laboratory markers for assessing disease activity in SLE?
Complement
ESR
dsDNA levels
Urinalysis
Which antibody marker is highly correlated with disease progress?
Anti-dsDNA antibody
What is the overall main pathophysiology of SLE, as it is understood now?
Due to poorly cleared apoptotic bodies which activates self-reactive lymphocytes, generating antibodies to host nuclear antigens and generating the autoimmune disease
What are the main treatments for SLE?
Corticosteroids, oral agents (hydroxychloroquine, methotrexate, etc), belimumab (anti-BLyS), rituximab (anti CD-20), epratuzumab (anti-CD22), anti-TNF-alpha
What is the target of belimumab?
Anti-BLyS
What is the target of rituximab?
Anti-CD20
What is the target of epratuzumab?
Anti-CD22
What are the main drugs that cause drug-induced lupus?
Procainamide, hydralazine, isoniazid, minocycline, pyrazinamide, penicillamine
What syndrome commonly occurs with SLE?
Antiphospholipid antibody syndrome which is when autoantibodies bind phospholipids and beta2-glycoprotein, resulting in arterial and venous thrombosis. Treatment is lifelong anticoagulation
What causes neonatal lupus?
Is caused due to passive IgG transfer, leads to heart block
