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2A2 11. gastro-intestinaal > systeemtherapie > Flashcards

systeemtherapie Flashcards

1
Q

huidige criteria voor resectie levermeta’s

A
  1. radicale resectie mogelijk van alle meta’s

2. voldoende resterend functionerend leverweefsel (20-30%)

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2
Q

wat doe je wanneer er te weinig functioneel leverweefsel over zou blijven?

A

lever groter maken middels vena porta emobilsatie

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3
Q

VEGF-remmer (bevacizumab)

A

remming van endotheelcellen en van vasculaire permeabiliteit -> minder angiogenense

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4
Q

EGFR-remmer (cetuximab, panitummab)

A

alleen effectief bij mensen zonder KRAS mutatie -> minder proliferatie en engiogenese

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5
Q

BRaF (encoragenib)

A

alleen effectief bij mensen met BRAF-mutatie

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6
Q

2 immunotherapeutische middelen

A
  1. CTLA-4 REMMERS -> grijpt in op interactie dendritische cel en t-cel
  2. PD-1 remmer -> grijpt in op interactie T-cel en tumorcel
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2A2 11. gastro-intestinaal (5 decks)

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