SYPHILIS Flashcards
Syphilis is cause by?
Treponema pallidum
Aka
Great imitator
Enumerate stages
Primary/ Early
Secondary
Latent/ hidden
Tertiary/ Late
Immunoglobulin that can be seen in primary stage
IgM
Signs/Symptoms in primary/early
Hard chancer
Signs/Symptoms in Secondary stage
Condyloma latum (wart-like lesson)
Immunoglobulin can be seen in Secondary stage
IgG
Hard chancer is painful or painless
Painless
Soft chancre is caused by
H. ducreyi
Signs/Symptoms in Tertiary/ late stage
Gummas/ gummatas
Tertiary/ late stage can cause
Neurosyphilis or cardiovascular syphilis
Screening test for syphilis (non- treponemal or treponemal)
Non-treponemal
Antigen use in screening
Cardiolipin
Antibody detected in screening test
Reagin
Meaning of VDRL
Venereal Disease Research Laboratory
Meaning of RPR
Rapid Plasma Reagin
Principle of non-treponemal test for syphilis
Flocculation ( a precipitation reaction)
Reagents of VDRL
-Cardiolipin
-Cholesterol
-Lecithin
Reagents of RPR
-Cardiolipin
-Cholesterol
-Charcoal
-Lecithin
Needs serum inactivation (VDRL or RPR)
VDRL
No serum inactivation (VDRL or RPR)
RPR
Reads microscopically (VDRL or RPR)
VDRL
Reads Macroscopically (VDRL or RPR)
RPR
180 rpm for 4 minutes (VDRL or RPR)
VDRL
100 rpm for 8 minutes (VDRL or RPR)
RPR
Gauge of needle use to dispense antigen form a small plastic dispensing bottle (RPR card test)
20 gauge
Reading and reporting of RPR Card Test. Medium or large clumps
Reactive
Reading and reporting of RPR Card Test. No clumping ( slightly roughness) + tail upon swirling
Nonreactive
Reading and reporting of RPR Card Test. Small clumps
Weakly reactive
