Synthetic Routes Flashcards
Alkane to Haloalkane
UV + X2 (halogen)
Free Radical Substitution
Haloalkane to Alcohol
NaOH (aq)
1 Alcohol to Aldehyde
K2Cr2O7/ H2SO4 + distillation
Aldehyde to Carboxylic acid
K2Cr2O7/H2SO4 reflux
Carboxylic Acid to Acyl Chloride
SOCl2
Acyl Chloride to Carboxylic Acid
H2O
1 Alcohol to Carboxylic Acid
K2Cr2O7/H2SO4 Reflux
Aldehyde to 1 Alcohol
NaBH4
Alcohol to Haloalkane
NaX + H2SO4
Alkene to Alkane
H2/Ni hydrogenation
Alkene to Haloalkane
HX or X2 electrophilic addition
Alkene to Alcohol
H3PO4 + H2O (steam)
Alcohol to Alkene
H3PO4 + heat (dehydration)
Haloalkane to Nitrile
KCN + ethanol
Haloalkane to Amine
NH3 + ethanol
Nitrile to Amine
H2 + Ni
Nitrile to Carboxylic Acid
H2O/ HCL + heat
Hydroxynitrile to Amine
H2/Ni
Ketone to Hydroxynitrile
NaCN/H+
2 Alcohol to Ketone
K2Cr2O7/ H2SO4 + reflux (oxidation)
Ketone to 2 Alcohol
NaBH4
Aldehyde to Hydroxynitrile
NaCN/H+
Hydroxynitrile to Carboxylic Acid
H2O/HCL + heat
Acyl Chloride to 1 Amide
NH3
Acyl Chloride to 2 Amide
1 amine (RNH2)
Acyl Chloride to Ester
alcohol
Carboxylic Acid to Ester
Alcohol + conc H2SO4
Ester to Carboxylic Acid
Dilute acid + heat
Ester to Carboxylate (salt)
Hydroxide (XOH) + heat
Alcohol to Ester
Carboxylic Acid + conc H2SO4
Or
Acid Anhydride