Syndrome of inappropriate ADH secretion Flashcards

1
Q

What is it?

A

Hyponatraemia caused by inappropriate secretion of ADH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Management

A

Fluid restriction
If this doesnt work:
- Demelocycline
- Tolvaptan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Demelocycline

A

Blocks renal tubular effect of ADH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Tolvaptan

A

Vasopressin antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Caution

A

Avoid rapid correction of hyponatraemia - causes osmotic demyelination of neurones = SERIOUS CNS SIDE EFFECTS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly