Synaptic Transmission/ CNS Transport

Question 1

L Dopa crosses the BBB through

Answer 1

facilitated diffusion, it has a low oil/water partition coefficient

Question 2

Arachnoid granules

Answer 2

one way valves into superior sagittal sinus

Question 3

CSF in subarachnoid hemorrhage

Answer 3

+protein, normal glucose, present RBC

Question 4

CSF in Giullon Barre

Answer 4

protein ++, normal glucose, few WBC

Question 5

Metastatic cancer in menenges CSF

Answer 5

+ protein, normal or decreased glucose, increased WBC

Question 6

Viral Meningitis CSF

Answer 6

+ protein, normal glucose, extensive WBC

Question 7

Bacterial Meningitis CSF

Answer 7

+protein, decreased glucose, increased WBC

Question 8

CSF vs Plasma

Answer 8

CSF has more Cl-, Mg, =/+Na

Question 9

Botulinum toxin target

Answer 9

cleaves synaptobrevin at terminal of peripheral motor neuron

Question 10

tetanus toxin target

Answer 10

cleaves synaptobrevin at inhibitory interneuron

Question 11

aminoglycoside antibiotics target

Answer 11

block voltage gated calcium channels

Question 12

4 aminopyridine target

Answer 12

block voltage gated k channgels