Synaptic transmission Flashcards
Synaptic transmission
The process by which neighbouring neurons communicate with each other by sending chemical messages across the synaptic cleft that separates them.
Neurotransmitters
Brain chemicals released from synaptic vesicles that relay signals across the synapse from one neuron to another. Neurotransmitters can be broadly divided into those that perform an inhibitory or an excitatory function
Excitation
When a neurotransmitter, such as adrenaline, increases the positive charge of the postsynaptic neuron. This increases the likelihood that the neuron will fire and pass on the electrical impulse.
Inhibition
When a neurotransmitter, such as serotonin, makes the charge of the postsynaptic neuron more negative. This decreases the likelihood that the neuron will fire and pass on the electrical signal.
2 Effects of Drugs on Synaptic Transmission
-Increasing the amount of neurotransmitter in the synaptic cleft by blocking the reuptake channels. (SSRIs)
-Decreasing the amount of neurotransmitter in the synaptic cleft by blocking the receptors (antipsychotics)