Synaptic Plasticity And Memory Flashcards
Which area(s) of the brain is mainly responsible for declarative (explicit memory)?
Hippocampus - medial temporal lobe
Diencephalon
Which area(s) of the brain is mainly responsible for skills and habits within implicit (non-declarative) memory?
Striatum, motor cortex and cerebellum
Which area(s) of the brain is mainly responsible for priming within implicit memory?
Neocortex
Which area(s) of the brain is mainly responsible for emotional responses within implicit memory?
Amygdala
Which area(s) of the brain is mainly responsible for skeletal musculature within implicit memory?
Cerebellum
Which area(s) of the brain is mainly responsible for non-associative learning within implicit memory?
Reflex pathways
The classical properties of LTP are often cited as relevant to its putative role in memory. What is the role of persistence in memory?
The memory outlasts its induction
The classical properties of LTP are often cited as relevant to its putative role in memory. What is the role of input specificity in memory?
Enough storage capacity
The classical properties of LTP are often cited as relevant to its putative role in memory. What is the role of associativity in memory?
To link information together
What is anterograde alteration?
Interventions that prevent or limit the induction of synaptic weight changes during a learning experience should block or impair the animal’s memory of that experience. Interventions enhancing plasticity might also improve learning
What are some issues associated with anterograde alteration?
What physiological, pharmacological or molecular-genetic manipulations to use? Side effects?
How to ensure appropriate regional specificity of the treatment for the type of learning/memory under investigation?
Inducibility and reversibility of the treatment?
For place memory what is necessary for the encoding of a memory?
Hippocampal NMDA receptor activation and the subsequent up regulation of GluA2-lacking AMPARs is necessary for the encoding of a memory
What is retrograde alteration?
Interventions that alter the spatial distribution of synaptic weights induced by prior learning should alter the animal’s memory of that experience
What are some issues associated with retrograde alteration?
What physiological, pharmacological or molecular-genetic manipulations to use? Side effects?
How to ensure appropriate regional specificity of the treatment for the type of learning/memory under investigation?
How soon after the prior learning experience?
What is detectability?
If an animal displays memory of some previous experience, a change in synaptic efficacy should be detectable somewhere in its nervous system
