Sympathomimetics part 2 Flashcards
NOREPI is __ to epi at β1, very little β2 actions.
Potent α1 producing intense vasoconstriction in arterial and venous vascular beds
Because is has ver little B2 = no bronchodilating effects!
equal
Norepi Increases BP by increasing __ , May trigger the baroreceptor reflex, increased __ can elicit a reflex bradycardia.
SVR
SVR
NE released during stress in brain stem’s __ ___, which is the origin of most NE pathways in the brain.
Noradrenergic neurons project from __ __ to the cerebral cortex, limbic system, and spinal cord.
Locus ceruleus
Locus ceruleus
NE is a catecholamine & phenethylamine derivative.
Stereoisomer - we use the dextro or levo form?
LEVOphed
NE is synthesized in adrenal medulla from the amino acid __, then oxidated to __, then de-carboxylated to __
tyrosine
L-DOPA
Dopamine
NE action is followed by signal termination - either by degradation of NE or by NE uptake by surrounding cells.
degradation OR uptake
What are the two major urinary metabolites of catecholamine metabolism?
VMA and MOPEG
Zach rode his mopeg to the vma’s to get an award for the best skiing wreck of the winter break.
Again, does NE activate B2?
No, no bronchodilating properties
Again, how do NE increase BP?
Alpha 1 and 2 agonist causing increased SVR
Dopamine is a Phenethylamine derivative that is released by hypothalamus, stimulates the __.
Stimulates the CTZ
Of all the dopamine receptors, only d1 and d_ have clinical significance
d1 and d2
D1receptor works post synaptically to __
vasodilation of renal, mesenteric, coronary, and cerebral blood vessels
D2 receptor works pre synaptically to __
inhibits the release of NE, (post-synaptic) weak vasoconstriction
Dopamine acts @
β1 receptors with 3-10mcg/kg/min doses,
α1 @ >10mcg/kg/min doses
A portion of dopamine’s + inotrope effect is from release of endogenous NE (indirect actions!)
“Renal Dose Dopamine” 1-3 mcg/kg/min implies dopamine only works at kidneys at this level
NOT TRUE