sympathetic pharmacology Flashcards
how is the structure of ganglionic neurones in sympathetic system?
preganglionic: short
postganglionic: long
what receptors mediate sweat gland activity?
mAchRs
are beta receptors innervated?
beta 1 receptor: innervated
beta 2: not innervated, responds to circulating adrenaline
where are beta receptors located?
beta1: heart, juxtaglomerular apparatus, adipose tissue
beta 2: located in bronchial smooth muscle, uterine smooth muscle, skeletal muscle vasculature
what are metabolic effects of adrenoceptors?
mainly beta2: activates adenylate cyclase
causes liver to convert glycogen to glucose and muscle to convert glycogen to lactic acid
describe alpha receptors
a1: post junctional heteroreceptor
a2: pre junctional autoreceptor