Sweatman Testiclular Cancer Drugs

Question 1

class of drugs for testicular cancer

Answer 1

Classical Cytotoxic agents

Question 2

cancer is found in only the testis

Answer 2

stage one

Question 3

cancer in lymph nodes in the abdomen

Answer 3

stage 2

Question 4

cancer beyong lymph nodes and in the abdomen

Answer 4

stage 3

Question 5

may be cancer in parts of the body far away from the testicles (lungs and liver)

Answer 5

stage 3

Question 6

most common solid tumor in men between 15-34 years old

Answer 6

testicular cancer

Question 7

one of the most chemo-sensitive and thus curative cancers

Answer 7

testicular cancer

Question 8

95% of testicular cancers are…

Answer 8

germ cell tumors classified as seminomas or non-seminomas

Question 9

serum tumor markers for testicular cancer

Answer 9

AFP
BetaHcg
LDH

Question 10

early sign of testicular CA relapse

Answer 10

rise in plasma marker levels

*therfore must measure before during and after treatment and thru follow up

Question 11

three PHASES of tx for testicular cancer

Answer 11

Sx
Radiotherapy
Chemo

Question 12

primary CHEMO for testicular cancer

Answer 12

Etopo/Cisplastin
Bleo/Etopo/Cis
Etopo/Mesna/Ifosfamide/Cisplatin

Question 13

second ling therapy for metatstic tumors

Answer 13

Vinblastine/mesna/Ifo/cis

>paclitaxel/mesna/ifo/cis

Question 14

all treatment options for testicular cancer involve

Answer 14

platinum agent

Question 15

high doe regimins involve what

Answer 15

peripheral stem cell infusions

Question 16

must be igven with ifosfamide

Answer 16

mesna

-renoprotective, protects against hemorrhagic cystitis

Question 17

dode limiting pulmonary fibrosis

Answer 17

bleomycin

dna strand breakage

Question 18

dose limiting renal toxicity

Answer 18

cisplatin

-nuclaer and mitochondrial DNA-oxidative stress

Question 19

dose limiting thrombocytopenia

Answer 19

same as cisplatin but slower and requires bigger dose

Question 20

dose limiting leukopenia

Answer 20

etoposide

Question 21

dose limiting myelosupresion

Answer 21

ifosfamide

alkylating agent-crosslinks

Question 22

dose limiting bone marrow supression

Answer 22

paclitaxel

inhibits depolymerization of microtubules

Question 23

doe limiting neuropathy

Answer 23

vinblastine

-disintegrates microtubules

Question 24

forms acrolein thioester bonds which are inactive

Answer 24

MESNA

Question 25

loss of sense of taste

Answer 25

MESNA

Question 26

ototoxicity

Answer 26

cisplastin

carboplatin

Question 27

used to prevent cisplatin toxicity

Answer 27

amifostine