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Cardiovascular > Sweatman Ganglionic Blockers > Flashcards

Sweatman Ganglionic Blockers Flashcards

1
Q

Ganglionic blockers function by target…

A

antagonists of cholinergic Nicotinic (Nn) receptors

*this in entirely seperate from muscarinic antagonism

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2
Q

Ganglionic blockers work at which location

A

sympathetic ganglia

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3
Q

drugs active at sympathetic affect

A

> BV=tone of vascular

>Heart directly

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4
Q

only ganglionic blocker

A

trimethaphan

*mecylamine (inversine)–>orphan drug for tourrettes

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5
Q

is trimethaphan widely used

A

no ganglionic blockers have been replaced by Rx’s in the tx of HTN with more specificity and less global effects on ANS

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6
Q

Neurotransmitter in preganglion for sympathetic

A

acetylcholine

*therefore it is non-specific

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7
Q

Neurotransmitter for preganglion for parasympathetic

A

acteylcholine

*therefore it is nonspecific

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8
Q

Ligand gated ion channels in post synaptic membrane

A

Nicotinic Acetylcholine receptors

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9
Q

initial epsp is mediated through

A

Nicotinic ach receptor

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10
Q

slow IPSP and slow EPSP is mediated through

A

Muscarinic M2 and M1 receptors

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11
Q

Late slow EPSP is mediated through

A

several peptidergic receptors

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12
Q

arteriole predominant tone

A

sympathetic (adrenergic)

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13
Q

effect of ganglionic blockade on arterioles

A

vasodilation–>increased peripheral blood flow

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14
Q

veins predominant tone

A

sympathetic tone (adrendergic_

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15
Q

effect of ganglionic blockade on veins

A

dilaiton–>peripheral pooling of blood, decreased venous return, decreased CO

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16
Q

predominant tone in the heart

A

parasympathetic (cholinergeric)

17
Q

effect of ganglionic blockade on heart

A

tachycardia

*loss of PS tone

18
Q

result of ligand binding to Nicotinic receptor

A

opening of Na and K channels and DEPOLARIZATION

19
Q

MOA FOR TRIMETHAPHAN and Mecylamine

A

compete with endogenous Ach for Nn receptor binding

*thereby tempering parasympathetic stimulation of postganglionic neurone

20
Q

Adverse effect of ganglionic blockers

A

postural hypotension, tachycardia (loss of PS tone on the heart), arrhythmias

21
Q

ancient ganglionic blocker that is no longer used

A

hexamathonium

Cardiovascular (6 decks)

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