SUSPENSION

Question 1

Preparations that contain finely divided particles ideally uniformity distributed though a vehicle in which drug exhibits minimum degree of solubility

Answer 1

Suspension

Question 2

What is the other name for finely divided particles of suspension?

Answer 2

Suspensoid

Question 3

2 phases of suspension

Answer 3

1. Dispersed phase
2. Dispersing phase / dispersion medium

Question 4

What phase of suspension is the drug/ powder /solid?

Answer 4

Dispersed phase

Question 5

What is the phase of suspension that is carrier / vehicles?

Answer 5

Dispersion medium or dispersing phase

Question 6

Mixture of two or more components

Answer 6

Suspension

Question 7

Very small pieces of solid are mixed in a liquid but do not dissolved

Answer 7

True

Question 8

If left still, the solid pieces will separate from the liquid and either fall to the bottom or rise to the top.

Answer 8

True

Question 9

Examples of suspension

Answer 9

Sand in water and flour in water

Question 10

Suspension may separate quickly or stay suspended for a long time depending on what they contain.

Answer 10

True

Question 11

Substance distributed is reffered?

Answer 11

Dispersed phase

Question 12

Vehicle is termed

Answer 12

Dispersing phase or dispersion medium

Question 13

Commonly referred to as dispersions in which the therapeutic agent is dispersed in the external phase (vehicle)

Answer 13

Pharmaceutical suspension

Question 14

Formulation considered

Answer 14

1. Drug
2. Wetting Agent
3. Suspending agent
4. Flocculating Agent
5. Preservatives
6. Sweeteners
7. Flavorants
8. Colorants

Question 15

Drug

Answer 15

1-50 micrometer
Water insoluble

Question 16

Wetting agent

Answer 16

surfactant that reduce surface tension and facilitate wetting of hydrophobic particles
-adsorb hydrophobic particles to either coat the surface or form a complete monolayer.

Question 17

Examples of Wetting Agent

Answer 17

Polysorbate 80, Sodium Lauryl Sulfate (SLS)

Question 18

Suspensing Agent

Answer 18

Hydrophilic colloids
Increase viscosity
Decrease sedimentation
Inhibit agglomeration

Question 19

Examples of suspending agents

Answer 19

Cellulose
Polymer
Gums

Question 20

Cellulose

Answer 20

Methyl cellulose
Hydroxypropyl cellulose
Sodium carboxy methyl cellulose

Question 21

Polymer

Answer 21

Povidone
Carbomer

Question 22

Gum

Answer 22

Tragacant gum
Carrageenan
Xanthan gum
Acacia gum

Question 23

Flocculating Agent

Answer 23

Electrolytes
Surfactant
Hydrophilic polymer

Question 24

Flocculation is the formation of loose, light and fluffy flocs held together by weak Van der Waals forces

Answer 24

True

Question 25

Deflocculation exhibit strong interparticles forces leading to aggregation (caking)

Answer 25

True

Question 26

Flocculating agent prevent caking Deflocculated agent increase tendency of caking

Answer 26

True

Question 27

Electrolyte

Answer 27

Reduce the electrical barrier between the particles

Question 28

Examples of electrolyte

Answer 28

Sodium salts of acetate, phosphate citrate

Question 29

Surfactants

Answer 29

Causes flocculations by neutralization of charge in the particles

Question 30

Surfactants example

Answer 30

SLS sodium lauryl sulfate

Question 31

Hydrophilic polymers

Answer 31

Exhibit psudoplastic that promotes physical stability by maintaining high viscosity when the suspension is stagnant

Question 32

Hydrophilic polymer

Answer 32

Starch Alginate Cellulose polymer Gum Carbomer Silicate

Question 33

Preservatives is added in aqueous suspension because sweeteners and suspending agents are good media for mbcrobial growth.

Answer 33

True

Question 34

Preservatives example

Answer 34

Alcohol - Ethanol -propylene glycol - benzyl alcohol Surfactants -benzalkonium chloride Acids -benzoic acid -sorbic acid Parabens -methyl parabens -propyl parabens

Question 35

Sweeteners

Answer 35

Reduced unpleasant taste of partially dissolves drufs

Question 36

Flavorants

Answer 36

Enhance patients acceptability And improve palatability

Question 37

Colorants

Answer 37

More esthetic appearance