Surgical Recall - Ch. 56 Breast Flashcards
Anatomy
- What are Rotter’s nodes?
- What is the mammary “milk line”?
- What is the “tail of Spence”?
- Which hormone is mainly responsible for breast milk production?
- Nodes between pectoralis major and minor muscles; not usually removed unless they are enlarged or feel suspicious intraoperatively
- Embryological line from shoulder to thigh where “supernumerary” breast aerolar and/or nipples can be found
- “Tail” of brast tissue that tapers into axilla
- Prolactin
Breast Cancer
- What option exists to decrease the risk of breast cancer in women with BRCA?
- What is the “TRIAD OF ERROR” for misdiagnosed breast cancer?
- What are the physical/anatomic risk factors for breast cancer?
Breast Cancer
- What option exists to decrease the risk of breast cancer in women with BRCA? Prophylactic bilateral mastectomy
- What is the “TRIAD OF ERROR” for misdiagnosed breast cancer?
- Age < 45 yrs
- Self-diagnosed mass
- Negative mammogram
- What are the physical/anatomic risk factors for breast cancer?
- Cancer in the breast
- Hyperplasia (2x)
- Atypical hyperplasia (5x)
- Female
- Elderly
- DCIS
- LCIS
- Inherited genes (BRCA I & II)
- Papilloma (1.5x)
- Sclerosing adenosis (1.5x)
Breast Cancer
- What are the different types of invasive breast cancer (6)?
- What is the most common type of breast cancer?
- What are the screening recommendations for breast cancer:
- Breast exam recommendations?
- Mammograms?
- Why is mammography more useful diagnostic tool in older women than in younger?
- Invasive types:
- IDC (75%)
- Medullary (15%)
- ILC (5%)
- Tubular (2%)
- Mucinous (1%)
- Inflammatory (1%)
- IDC
- Screening recommendations:
- Breast exam: Self-exam monthly; ages 20-40: breast exam every 2-3 years by a physician; >40 years: annual exam
- Mammograms: Baseline mammogram between 35 and 40; mammogram every year > 50
- Breast tissue undergoes fatty replacement with age, making masses more visible; younger women have more fibrous tissue, which makes mammograms harder to interpret
Breast Cancer
- What is the classic picture of breast cancer on mammogram?
- Wich option is best to evaluate a breast mass in a woman younger than 30 years?
- What is obtained first, the mammogram or the biopsy?
- What would be suspicious mammographic findings?
- Spiculated mass
- Breast U/S
- Mammogram is obtained first; otherwise, tissue extraction (core or open) may alter the mammographic findings (FNA may be done prior to mammogram b/c the fine needle usually will not affect the mammographic findings)
- Mass, microcalcifications, stellate/spiculated mass
Breast Cancer
- What is the “workup” for a breast mass?
- How do you proceed if the mass appears to be a cyst?
- What is the pre-op staging workup in a pt with breast cancer?
- Workup:
- Clinical breast exam
- Mammogram or breast U/S
- FNA, core biopsy, or open biopsy
- Aspirate cyst
- Pre-op staging workup:
- Bilateral mammogram (cancer in one breast is a risk factor for cancer in the contralateral breast!)
- CXR (check for lung mets)
- LFTs (check for liver mets)
- Serum calcium level, AP (if these tests indicate bone mets, proceed to bone scan)
- Head CT (if pt has focal neurologic deficit to look for brain mets)
Breast Cancer
- What breast carcinomas are candidates for lumpectomy and radiation (breast-conserving therapy)?
- What is the treatment of inflammatory carcinoma of the breast?
- What is a sentinel node biopsy?
- Can tamoxifen prevent breast cancer?
- What are the side effects of tamoxifen?
- Stage I and stage II (tumors < 5 cm)
- Chemo first! Then often followed by radiation, mastectomy, or both!
- Instead of removing all the axillary lymph nodes, the primary draining or “sentinel” lymph node is removed
- Yes! Reduce risk by 50%
- Endometrial cancer (2.5x relative risk), DVT, PE, cataracts, hot flashes
Fibrocystic Change
- What is it?
- What are the signs/symptoms?
- How it is diagnosed?
- Treatment for symptomatic fibrocystic disease?
- What is done if the pt has a breast cyst?
Fibrocystic change
- Common benign breast condition consisting of fibrous and cystic changes
- Breast pain or tenderness that varies with menstrual cycle
- Multiple, diffuse nodulocystic masses (CORDLIKE THICKENING)
- No nipple discharge
- Through breast exam, history, and aspirated cysts (usually green fluid)
- STOP CAFFEINE; pain meds (NSAIDS), vitamin E
- Needle drainage: if aspirate is bloody, open biopsy… if aspirate is green, follow pt closely
Miscellaneous
- What is the most common cause of bloody nipple discharge in a young woman?
- What is the most common breast tumor in pts younger than 30 years?
- What is Paget’s disease of the breast?
- What are the common options for breast reconstruction after a mastectomy?
- Intraductal papilloma
- Fibroadenoma
- Scaling rash/dermatitis of the nipple caused by invasion of skin by cells from a ductal carcinoma
- Saline implant / TRAM flap
Benign Breast Disease
- What is the most common cause of green, or brown nipple discharge?
- What is the most common cause of breast mass after breast trauma?
- What is Mondor’s disease?
- What must be r/o with spontaneous galactorrhea?
- Fibrocystic disease
- Fat necrosis
- Thrombophlebitis of superficial breast veins
- Prolactinoma (check pregnancy test and prolactin level)
What is the major difference in the subsequent development of invasive breast cancer with DCIS and LCIS?
LCIS cancer develops in either breast; DCIS cancer develops in the ipsilateral breast
Incisional biopsy of a breast mass in a 35 y/o woman demonstrates cystosarcoma phyllodes at the time of frozen section. Which of the following is the most appropriate mgmt strategy for this lesion?
a. Wide local excision with a rim of normal tissue
b. Lumpectomy and axillary lymphadenopathy
c. Modified radical mastectomy
d. Excision and post-op radiotherapy
a. Wide local excision with a rim of normal tissue