Surgical Basics + Anaesthetics Flashcards
List 6 methods of preventing Post-op DVT
Pre op mobilisation
Post op mobilisation
Graduated compression/ Anti-embolism stockings
Intra-operative intermittent calf compression
Maintain hydration
Stop pro-thrombotic drugs
Compare effectiveness of;
- LMWH started within 12hrs of finishing surgery
- LMWH started before surgery
Suggest 2 reasons why this may be? (Need to check if these are true)
Just as effective
- Reduced renal blood flow in 3day post-op phase, so in both cases les heparin is being excreted
- Half life of 2hrs, so steady state reached at 10-12hrs after starting LMWH. Heparin is stopped before surgery anyway. (24hrs, 12 if prophylactic)
Why must 4hrs have passed since epidural insertion, before administering LMWH?
(Some sources say 2hrs after removal)
Risk of Epidural or Spinal Haematoma
Bleeding into spinal canal can cause Spinal Cord Ischaemia, Parapelgia
(Risk also present with removal of epidural catheter)
(Insertion of epidural catheter should be delayed until anticoagulant effect of medication is minimal: Usually 8–12 hrs after a SC dose of heparin or a BDS prophylactic dose of LMWH, or at least 18 hrs after an ODS prophylactic dose of LMWH)
Who is eligible to give blood
Fit and healthy
Between 50 and 158kg
Between 17 and 66 (70 if given blood before)
Over 70, if given full blood donation in last 2 yrs
How often can blood be given
Men- every 6wks
Women- every 12wks
Who can’t give blood
Possible HIV, HTLV or Hepatitis
Previously had Syphilis, even if treated
Ever injected/ been injected with drugs (may be able to if prescribed)
Taking Pre-Exposure or Post-Exposure Prophylaxis (PrEP or PEP)
People who have had a transfusion
What is blood regularly checked for before being sent to blood bank?
Other than blood type
Syphilis, HIV, Hep B, Hep C, Hep E
HTLV (Human T-lymphotropic Virus)
List some additional tests that may be done on blood being given for donation
Malaria, T-Cruzi (Can cause Chagas disease)
WNV, West Nile Virus, CMV
Non-specific reactivity (doesn’t affect donor’s health)
How long does a full cross match of blood take?
45mins
How long can you wait after eating and drinking for anaesthetic administration
6-8hrs food, 2 hrs clear fluid
Outline Rapid Sequence Induction, RSI
Used if an emergency surgery needed on someone who isn’t starved
Anaesthetic agent as uscle relaxant
ODP presses on Cricoid cartilage to prevent reflux
Anaesthetist puts in ET tube and blows up balloon so that refluxed food doesn’t go beyond pharynx
Which vasopressor is commonly used to manage sepsis
Noradrenaline
Define septic shock
Lactate >4mM
Systolic = 90mmHg, not responsive to IV fluids
OR
MAP <70mmHg, not responsive to IV fluids
How long can RBCs be stored in refrigerator and freezer
42 days fridge, 10yrs freezer
What is Fresh Frozen Plasma (FFP) used for?
(Can be used to prepare Cryoprecipitate, contains Clotting Factors)
How long can it be stored in freezer
To provide coagulation factors or treat shock due to plasma loss (Burns or bleeding)
1yr in the freezer
What is Concentrate of platelets
How long can it be stored at room temp (Only stored this way)
To treat/ prevent bleeding due to low platelet levels
5 days at room temperature
What is Cryoprecipitate used for?
How long can it be stored in freezer
(Contains Fibrinogen and Factor VIII)
To treat fibrinogen deficiency (Given with Frozen Plasma, to absorb Coag factors)
1yr in freezer
When does the ABO blood group develop in a new-born
After 3mths of life, due to lack of immune system and antigenic exposure
How long should a blood transfusion take?
A couple hours, maximum 4 hrs
Define a massive blood transfusion
Replacement by transfusion of 10 units of RBCs in 24hrs
List 5 Acute Transfusion Reactions
Acute Haemolytic Transfusion reaction (Fever, Chills, HypoT, TachyC, Flank pain, Haemoglobinuria)
- Anaphylaxis
- Urticarial reaction (Only urticaria)
- Febrile non-haemolytic transfusion reactions (Idiopathic >1 degree temp. rise)
TRALI (Dyspnea, Hypoxia, non-Cardiogenic pulmonary oedema)
What can TRALI be confused for?
TACO- Transfusion associated circulatory overload
Biggest cause of death
How can pts’ Hb be optimised before surgery
- Oral iron
- EPO
- Consider stopping antiplatelets/ coagulants
List some blood alternatives
Iron (Supplements, Diet, IV iron)
EPO/ ESAs (Erythropoiesis Stimulating Agents)
PAD (Preoperative Autologous Blood Donation)
If normal renal function, Hhow long should pt not take DOACs prior to;
- Surgery with low bleeding risk
- Surgery with high bleeding risk
Low risk: 24hrs
High risk: 48hrs
Compare Colloids to Crystalloids
Crystalloids: Smaller molecules, Immediate fluid resuscitation, may cause Oedema
Colloids: Increase Oncotic Pressure, More costly, Can cause Anaphylaxis, AKI, Clotting disorders
Outline the 4 stages of blood loss
1: Upto 750ml
2: Upto 1.5L
3: Upto 2L
4: >2L
List 3 general transfusion complications
Clotting abnormalities (Dilution effect as packed RBCs don’t have clotting factors)
Electrolyte abnormalities (Low Ca or High K)
Hypothermia (Monitor core body temp)