Surg Path

Question 1

SMARCA4 protein

Answer 1

BRG1

Question 2

Yes or no: Pulmonary Langerhans cell histiocytosis is associated with smoking?

Answer 2

Yes, in almost every case

Question 3

Where is the most common location for cardiac myxomas to arise

Answer 3

Left atrium near fossa ovalis

Question 4

What percentage of cardiac myxomas arise in patients with Carney complex?

Answer 4

<10%

Question 5

Carney Complex

Answer 5

Skin pigmentation
Cardiac and soft tissue myxomas
Endocrine abnormalities

Question 6

Staining profile of Cardiac myxoma

Answer 6

CD31+
CD34+
Vimentin+
Calretinin+

Question 7

Histology of odontogenic keratocyst

Answer 7

8-10 cell layers thick
Basal palisading with hyperchromatic nuclei
Parakeratosis with corrugated appearance

Question 8

WHO name for OKC

Answer 8

KCOT

Keratinizing cystic odontogenic tumor

Question 9

Multiple OKCs think….

Answer 9

Nevoid basal cell carcinoma syndrome

Question 10

Histologic features of ameloblastoma

Answer 10

Palisaded basal epithelium with hyperchromatic nuclei, reverse polarity, and sub nucleolar vacuolization

Question 11

Odontomas with multiple tooth like structures?

Answer 11

Compound

Question 12

Odontoma with singular haphazardly organized tooth structures

Answer 12

Complex odontoma

Question 13

Differential for jaw giant cell lesions

Answer 13

Central giant cell (reparative) granuloma
Cherubism
Brown tumor of hyperparathyroidism

Question 14

What small vessel vasculiditis can cause pulmonary renal syndrome?

Answer 14

Anti-GBM disease
ANCA disease
Immune complex mediated disease (i.e lupus)

Question 15

Solitary fibrous tumor immunoprofile?

Answer 15

CD34+
STAT6+
BCL2+
CD99+
CK -

Question 16

What are Gamna-Gandy bodies and where are they found?

Answer 16

Calcified degenerating elastic fibers found in cardiac myxomas and the spleen in patients with sickle cell disease.

Question 17

What percentage of cardiac myxomas have EMH.

Answer 17

5-10%

Question 18

SMARCB1 gene

Answer 18

INI-1

Question 19

SMARCA2

Answer 19

BRM

Question 20

Bullous pemphegoid histology and DIF pattern?

Answer 20

Unilocular subepidermal blister

DIF shows linear IgG and C3 at epidermal-dermal junction

Question 21

Bullous pemphigoid has antibodies against this structure?

Answer 21

Hemidesmosome (BPAg1, BPAg2)

Question 22

Peripheral ossifying fibroma histology?

Answer 22

Cellular fibrous connective tissue with trabecular bone formation

Question 23

Where do most cardiac fibroelastomas arise?

Answer 23

90% are on the valve surfaces away from lines of closure

Question 24

Cardiac rhabdomyomas most commonly arise in?

Answer 24

Left ventricle and septum

Question 25

What is a radical at cyst?

Answer 25

Cyst associated with the apex of a non-vital tooth.

Question 26

What is another name for calcifying odontogenic cyst and what is its histology?

Answer 26

• Gorolin cyst
• Palisaded, hyperchromatic basal layer with loose epithelium reminiscent of stellate reticulum which calcifies and contains ghost cells.
• Reverse polarity and subnuclear vacuolization May be present.

Question 27

What are the two most common cardiac sarcomas?

Answer 27

1. Angiosarcoma

2. Undifferentiated pleomorphic sarcoma

Question 28

Which vascular marker is the most sensitive for angiosarcoma?

Answer 28

CD31

Question 29

Asbestos exposure has been associated with this cardiac sarcoma?

Answer 29

Synovial sarcoma