Surface Tension, Dissolution and Routes of Admin Flashcards
what is soluability?
the mass of the solute that dissolves in a specific mass or volume of a solvent at a given temperature
what is dissolution?
the process by which a solid drug substance becomes dissolved in a solvent
what is heat of fusion?
the amount of heat absorbed or released as the system changes its thermodynamic state
what does agitation of the dissolution medium cause a change in?
thickness of diffusion layer
what does viscosity of the solution cause a change in?
diffusion coefficient
what does particle size, wetting and porocity cause a change in?
surface area
what does the crystalline form of the drug cause a change in?
saturation solubility of the drug
what does the volume of the solution cause a change in?
the concentration of the drug in the bulk
how can drug dissolution be measured? (5)
- beaker method
- flask stirrer method
- rotating basket method
- paddle method
- flow through cell for low solubility drugs
what is an interface?
the contact area between two phases e.g liquid-vapour
