Suppositories, Inserts, Medication Sticks and Drug Delivery System for Vaginal Administration

Question 1

Absorption into the _____ causes first- pass effect

Answer 1

Superior Hemorrhoidal Vein

Question 2

No esterase or peptidase activity is present in the _____, resulting in a much greater stability of peptide-like drugs

Answer 2

Rectum

Question 3

Absorption may be directly into the _______, and bypass the liver

Answer 3

Superior Vena Cava

Question 4

Uptake is via _____ via _____

Answer 4

transcellular absorption; pH-partition
hypothesis

Question 5

For the treatment of local conditions, like haemorrhoids, ____ are used widely

Answer 5

fatty ointments

Question 6

Largest single-use category OTC

Answer 6

Haemorrhoidal treatment

Question 7

Rectal suppository bases can be classified broadly into two types:

Answer 7

fatty and water soluble or water
miscible

Question 8

Have difficulty disintegrating due to low amount of water present in the rectum

Answer 8

Rectal Tablets

Question 9

Blood drainage from the vagina is via the vaginal vein. From here the blood moves into the ______ and thus avoids the ____, i.e. the drugs absorbed through vaginal wall bypasses first-pass metabolism in liver

Answer 9

inferior vena cava; hepatic portal system

Question 10

Vaginal suppositories (pessaries) are most often
prepared with ______. _______- are less common since they are said to promote irritation. ______ are little used, since they promote discomfort on the side of the patient

Answer 10

Glycerol-gelatin bases; Polyethylene glycols; Fatty excipients

Question 11

May be a problem for drugs that are prone to hydrolysis. Require an applicator, applicators are messy in use and delivering an accurate dose is difficult. Single-dose preparations (3-5mL) are preferred

Answer 11

Vaginal semisolids

Question 12

Preferred for drugs that are prone to hydrolysis, and in countries that are tropical

Answer 12

Vaginal tablets

Question 13

Left in the vagina typically for longer periods than vaginal medicated tampons

Answer 13

Vaginal rings

Question 14

Local action, Irrigation, or Diagnostics
excipients may be added for enhanced stability

Answer 14

Vaginal solutions, emulsions, and suspensions

Question 15

The functional length of the urethra (from the bladder neck) in females is approximately _ cm; in the male, approximately _ to _ cm

Answer 15

3; 4 to 5

Question 16

*diameter: __;
*length: __ female, __ male;
*weight: __ female, __ male.

Answer 16

5 mm;
50 mm; 125 mm;
2 g; 4 g;

Question 17

There is reluctance with _____ as a rectal suppository base because of its relatively slow dissolution

Answer 17

glycerinated gelatin

Question 18

The rate of spreading and the rate of transportation to the rectal fluid is partially based on

Answer 18

viscosity

Question 19

It should be stated as a general rule that __ emulsion-type suppositories are strongly discouraged as the probability of drug transfer to the inner phase is high, and drug absorption may become reduced.

Answer 19

w/o

Question 20

Most commonly used method for production of
suppository on both small & large scale.

Answer 20

Pour molding