Suppositories

Question 1

Preparation of Suppositories

Answer 1

1. Molding or Fusion :(Melt and Pour method)
2. Hand Rolling and shaping.
3. Compression

Question 2

Molding

Answer 2

1. Melt the base.
2. Incorporate drug.
3. Pour the melt into molds.
4. Allow to cool and congeal.
5. Remove from mold ( when using metal molds)

Question 3

Fatty Base ( cocoa butter)

Answer 3

Lubricant : glycerin

Question 4

Aqueous Base (PEG)

Answer 4

Lubricant : liquid paraffin, mineral oil

Question 5

Compression

Answer 5

similar to hand rolling and shaping but instead of hand rolling the mixed mass is forced into a special mold.

Question 6

Oil soluble drug : oily base

Answer 6

Slow Release

Question 7

Water soluble drug: Oily base

Answer 7

Rapid Release

Question 8

Oil soluble drug: Water miscible base

Answer 8

Moderate Release

Question 9

Water –miscible drug: Water miscible base

Answer 9

Moderate release

Question 10

Synthetic Fats Bases

Answer 10

1. Fattibase
2. Wecobee
3. Witepsol

Question 11

Benefits of using synthetic fat bases

Answer 11

• Their solidifying points not affected by over heating -> no polymorphism problem.
• Have good resistance to oxidation thus more stable during storage.
• High softening point grades great for hot climates.
• Problem: more brittle than cocoa butter. This problem can be avoided by not placing in freezer and temperature

of the mold

Question 12

Polymorphism

Answer 12

• Occurs due to high proportion of unsaturated triglycerides.
• Occurs due to varying degrees of heating and cooling and condition during process.
• Different forms of polymorphs have different melting point and drug release rates.