Superantigen Toxin Mediated Illnesses

Question 1

Toxin mediated strep and staph dz

Answer 1

Necrotizing fasciitis, recalcitrant erythematous desquamating disorder, Scarlet fever, SSSS, strep/staph toxic shock, Possible others include atopic derm/guttate psoriasis/Kawasakii

Question 2

Toxic shock syndrome

Answer 2

Staph TSS can be associated with any staph infection (blood cx usually negative). Strep TSS usually associated with severe necrotizing skin infxn (blood cultures often positive)

Question 3

Skin findings in toxic shock syndrome

Answer 3

Can look like Kawasakii or Scarlet fever, diffuse scarlatiniform erythroderms, bulbar conjunctiva hyperemia, and palmar edema. Desquamation of the tips of fingers and toes occurs in 1-2 weeks after onset

Question 4

Tx of Toxic Shock symdrome

Answer 4

Clindamycin inhibits toxin production