Summer E1 Neuro Anxiety

Question 1

Anxiety

Med classes and meds

Answer 1

SSRIs/SNRIs *DOC Chronic GAD, SAD, Panic Disorder

Benzodiazepines (Very effective, fast) “-azepam”

Diazepam, Clonazepam, Temazepam, Lorazepam,

Alprazolam (Xanax), Chlordiazepoxide, Chlorezepate

Buspirone

Hydroxyzine

BB Propranalol, Pindolol, Atenolol

Question 2

Benzodiazepines

MOA

Answer 2

enhance transmission of GABA (inhibitory NT)

Question 3

BZ with fastest onset

Answer 3

Diazepam

only takes 15 min

Question 4

BZ that is ok to use with

hepatic dysfunction

Answer 4

Lorazepam

Question 5

BZs effective for depression?

Answer 5

NO!

Question 6

BZs

AEs

Answer 6

CNS depressive effects

cognitive effects - poor recall, anterograde AMNESIA

disinhibition

Question 7

BZ

• = effectiveness?*
• dosing similar?*

Answer 7

Effective at equivalent dose,

but. .
* Significant differences in dosing!!*

Question 8

BZ

Taper needed?

Answer 8

YES

Question 9

What the heck is

Buspirone?

• MOA*
• Benefit*

Answer 9

Anti-anxiety med, NOT effective for depression

• MOA:* 5HT-1a partial agonist.. ↓ presynaptic 5HT firing
• Benefit:* Not addictive, less strong

Question 10

Buspirone

• AE*
• Interactions*

Answer 10

• AE* dizziness, headaches, nausea
• Interactions*

MAOIs!!!

CYP3A4 inducers & inhibitors :

(Verapimil, Diltazem, Itraconazole, Fluvoxamine, Erythromycin)

Question 11

Hydroxizine

• MOA*
• AE*
• Use & Benefits*

Answer 11

MOA: H1 Blocker

AE: sedation, anticholinergic

.. less desirable for l/t tx

Use & Benefits: helps with SOMATIC sx (hr/sweating),

can use PRN/scheduled, not addictive

Question 12

BB

• AE*
• Use & Benefits*

Answer 12

• AE* HR, BP drop.. dose related, limits use
• Use & Benefits*

Helps with SOMATIC sx

Not addictive

Can be used PRN/scheduled