Summer E1 Neuro Anxiety Flashcards
Anxiety
Med classes and meds
SSRIs/SNRIs *DOC Chronic GAD, SAD, Panic Disorder
Benzodiazepines (Very effective, fast) “-azepam”
Diazepam, Clonazepam, Temazepam, Lorazepam,
Alprazolam (Xanax), Chlordiazepoxide, Chlorezepate
Buspirone
Hydroxyzine
BB Propranalol, Pindolol, Atenolol
Benzodiazepines
MOA
enhance transmission of GABA (inhibitory NT)
BZ with fastest onset
Diazepam
only takes 15 min
BZ that is ok to use with
hepatic dysfunction
Lorazepam
BZs effective for depression?
NO!
BZs
AEs
CNS depressive effects
cognitive effects - poor recall, anterograde AMNESIA
disinhibition
BZ
- = effectiveness?*
- dosing similar?*
Effective at equivalent dose,
but. .
* Significant differences in dosing!!*
BZ
Taper needed?
YES
What the heck is
Buspirone?
- MOA*
- Benefit*
Anti-anxiety med, NOT effective for depression
- MOA:* 5HT-1a partial agonist.. ↓ presynaptic 5HT firing
- Benefit:* Not addictive, less strong
Buspirone
- AE*
- Interactions*
- AE* dizziness, headaches, nausea
- Interactions*
MAOIs!!!
CYP3A4 inducers & inhibitors :
(Verapimil, Diltazem, Itraconazole, Fluvoxamine, Erythromycin)
Hydroxizine
- MOA*
- AE*
- Use & Benefits*
MOA: H1 Blocker
AE: sedation, anticholinergic
.. less desirable for l/t tx
Use & Benefits: helps with SOMATIC sx (hr/sweating),
can use PRN/scheduled, not addictive
BB
- AE*
- Use & Benefits*
- AE* HR, BP drop.. dose related, limits use
- Use & Benefits*
Helps with SOMATIC sx
Not addictive
Can be used PRN/scheduled