Summer E1 Neuro Anxiety Flashcards

1
Q

Anxiety

Med classes and meds

A

SSRIs/SNRIs *DOC Chronic GAD, SAD, Panic Disorder

Benzodiazepines (Very effective, fast) “-azepam”

Diazepam, Clonazepam, Temazepam, Lorazepam,

Alprazolam (Xanax), Chlordiazepoxide, Chlorezepate

Buspirone

Hydroxyzine

BB Propranalol, Pindolol, Atenolol

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2
Q

Benzodiazepines

MOA

A

enhance transmission of GABA (inhibitory NT)

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3
Q

BZ with fastest onset

A

Diazepam

only takes 15 min

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4
Q

BZ that is ok to use with

hepatic dysfunction

A

Lorazepam

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5
Q

BZs effective for depression?

A

NO!

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6
Q

BZs

AEs

A

CNS depressive effects

cognitive effects - poor recall, anterograde AMNESIA

disinhibition

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7
Q

BZ

  • = effectiveness?*
  • dosing similar?*
A

Effective at equivalent dose,

but. .
* Significant differences in dosing!!*

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8
Q

BZ

Taper needed?

A

YES

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9
Q

What the heck is

Buspirone?

  • MOA*
  • Benefit*
A

Anti-anxiety med, NOT effective for depression

  • MOA:* 5HT-1a partial agonist.. ↓ presynaptic 5HT firing
  • Benefit:* Not addictive, less strong
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10
Q

Buspirone

  • AE*
  • Interactions*
A
  • AE* dizziness, headaches, nausea
  • Interactions*

MAOIs!!!

CYP3A4 inducers & inhibitors :

(Verapimil, Diltazem, Itraconazole, Fluvoxamine, Erythromycin)

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11
Q

Hydroxizine

  • MOA*
  • AE*
  • Use & Benefits*
A

MOA: H1 Blocker

AE: sedation, anticholinergic

.. less desirable for l/t tx

Use & Benefits: helps with SOMATIC sx (hr/sweating),

can use PRN/scheduled, not addictive

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12
Q

BB

  • AE*
  • Use & Benefits*
A
  • AE* HR, BP drop.. dose related, limits use
  • Use & Benefits*

Helps with SOMATIC sx

Not addictive

Can be used PRN/scheduled

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