Summary of infectious diseases Flashcards

1
Q

The infectious disease history

A
PC
HPC
*EPIDEMIOLOGICAL HISTORY*
-travel, vaccine and prophylaxis history, occupation, food/ drink, reacreational, sexual, animal contacts, special medical procedures, contacts
PMH
-relevant to infectious disease
DH
FH
SH
SE (systemic enquiry)
-RS, CVS, GIT, GUT, CNS, MS, SS
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2
Q

Travel - commonest problems

A
Diarrhoea
-E.coli, Salmonella, Campylobacter, viral
Respiratory Tract Infections
-usually viral, Legionella
UTIs
Skin/ soft infections (insect bites)
Hepatitis (A)
Malaria
Typhoid
Dengue
Viral haemorrhagic fever
Avian Influenza
Middle Eastern Repiratory Syndrome - Coronavirus
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3
Q

Malaria - high rates

A

Central, E, W, Africa
S Africa (regional)
South Asia
SE Asia

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4
Q

Typhoid - high rates

A

Central, E, W Africa
South Asia
SE Asia

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5
Q

Dengue - high rates

A

Central America
South Asia
SE Asia
Australia/ S. Pacific

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6
Q

Viral haemorrhagic fever - high rates

A

Sporadic in E & West Africa

Eastern Europe and Central Asia

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7
Q

Avian Influenza - high rates

A

SE Asia

Middle East

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8
Q

MERS CoV

A

Middle East

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9
Q

Vaccine and prophylaxis history

A
Prophylaxis 
-malaria for recent travel
Vaccines
-travel (Hep A; typhoid; Neisseria)
-general (childhood schedule)
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10
Q

Occupation

A
• Health Care Workers
-blood borne viruses, LRTIs, diarrhoea
• Farm Workers
-leptospirosis, coxiella, orf
• Sewage Workers
-Leptospirosis, Hep A, gastroenteritis
• Sex Workers
-HIV, HepB, HSV, gonococcus, syphilis, chlamydia etc. 
• Pet Shop owners
-psittacosis
• Abbatoir Workers
-anthrax
• Military
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11
Q

Sexual history

A
• Recent partners – new?
• Number of partners
• Male or Female or Both
• CSW?
• Use of condoms
• Travel sexual history (of index and partner)
• STI’s? STI screens?
– HIV, Hepatitis B, EBV, CMV, gonococcus,
chlamydia, syphilis, HSV, also UTI
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12
Q

Sports

A
• Canoeists
-leptospirosis, gastroenteritis
• Cavers
-histoplasmosis, marburg
• Trekkers
-lyme disease, other tick-borne diseases
• Rugby Players
-HSV, fungal infections
• Swimmers 
-fungal infections, pox viruses, leptospirosis, gastroenteritis
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13
Q

Drug abuse

A
IV drugs
-Hep C, Hep B, HIV, endocarditis, skin and soft tissue infection including anthrax, aspergillus
Cannabis smokers
-pneumonia, early COPD, lung abscess
Alcoholism
-TB, pneumonia, HIV
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14
Q

Pets

A
• Dogs
-Campylobacter species, Toxacara, rabies
• Cats
-Toxoplasma
• Rodents
-rat bite fever, salmonella
• Terrapins
-salmonella
• Psittacine Birds
-chlamydia psittaci
• Tropical Fish
-mycobacterium marinum
• Wild and Domestic Fowl
-avian influenza
• Agricultural animals (city farms etc) 
-coxiella spp., salmonella, E.coli (e.g. 0157)
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15
Q

Relevant past medical history

A
• Head Injury
-meningitis (especially pneumococcal)
• Cancer
• Use of immunosuppression
-CMV, VZV, PCP, neutropenic sepsis (bacteria, fungi)
• Splenectomy
-pneumococcal bacteraemia
• Dentistry
-endocarditis
• Previous history of infectious disease
-especially meningitis, pneumonia, cellulitis
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16
Q

Special medical procedure

A
• Blood Transfusions/Blood products
-HIV, HBV, HCV, malaria!, prions
• IV cannula
-skin and soft tissue sepsis (bacterial)
• Prosthetic joints or heart valves
-serious persistent bacterial infections
• IUCD
-actinomycosis
• Body piercing
-skin sepsis
17
Q

Contacts

A

• Tuberculosis
• Sexually transmitted infections including
HIV
• Meningococcal Disease
• Shingles, Chicken Pox
• Measles, Rubella, Mumps
• Diarrhoea (viruses, food borne outbreaks)

18
Q

Principles of infection exam and tests

A

Response to infection
-systemic: fever/ malaise, vital signs, CRP/ white cells, rashes
-local: inflammation, destruction, abscess
-specific: antibody or cell mediated
Isolate pathogen
-sterile site: blood, CSF, urine, bone/ joint
-non sterile site: skin, gut, resp tract

19
Q

Diagnosing infection

A
Isolate a pathogen
-PCR
-stool sample
-culture bacteria
-blood test
Detect specific immune response
-e.g. Hep A serological response (anti-HAV IgM --> anti-HAV IgG)
-e.g. tuberculin skin test "Mantoux" or "Heaf" (T cell response)