Sulfanomides/Quinolones Lect 17 Flashcards
topical use for trachoma, 30% of the solution have a pH of 7.4
sulfacetamide
topical use only, elemental silver has antibacterial activity; prophylaxis of burn patients, little to no pain
silver sulfadiazine
Split by intestinal flora to yield 5-amino-salicylate and sulfapyridine; Treatment of ulcerative colitis and other inflammatory bowel disease, salicylate has therapeutic value
sulfasalazine
Chloroquine resistant falciprum malaria. High incidence of dermatitis reactions; rapidly absorbed and ultra long half life; 9 days
sulfadoxine and pyrimethamine
treatment of toxoplasmosis; rapidly absorbed and intermediate half life about 18 hours
sulfadiazine+pyrimethamine
single dosage containing equal amounts of each sulfa, reduces incidence of crystalluria
triple sulfa: sulfadiazine, sulfamerazine, sulfamethazine
most commonly used single sulfa; highest urine solubility and shortest acting
sulfisoxazole
Usually administered as a fixed combination ratio with trimethoprim; urine solubility is less than sulfisoxazole; intermediate acting
sulfamethaxazole
SMZ TMP therapeutic uses
Respiratory Infections and ear infections- Strep Pnuemonaie and H influenzae UTI Shigella and Salmonella Pneumocystis Carinii Jiroveci Toxoplasmosis and plasmodium
what organisms are capable of pumping fluoroquinolones?
Pseudomonas aeruginosus, staph and mycobacterium
list the three known fluroquinolones from this lecture
ciprofloxacin, levofloxacin, moxifloxacin
Most fluoroquinolones don’t penetrate well into the CNS except
levofloxacin
the primary way of excretion for flouroquinolones is ____ except for
renal excretion and some are the excreted non-renally as metabolites; moxifloxacin
the tendon ruptures are actually most common in people taking
flouroquinolones and corticosteroids
which drugs can interfere with warfarin and theophylline metabolism
ciprofloxacin and levofloxacin
