Sugammadex

Question 1

What is the mechanism of action of sugammadex?

Answer 1

• Encapsulates and prevents the actions of NMBA

_{UpToDate - Sugammadex: Drug Information}

Question 2

Sugammadex is a selective reversal agent that only works on which class on NMBA?

Answer 2

• Nondepolarizers, aminosteroid compounds

_{UpToDate - Sugammadex: Drug Information}

Question 3

What dose of sugammadex should be administered to a patient with a deep block (post-tetanic count of >2 and prior to second twitch return on TOF)?

Answer 3

• 4 mg/kg

_{Anesthesia Guidebook - Episode 18: Anesthesia Top Drawer Run Down - Part 2
Nagelhout (7th ed.), p. 176 - Table 12.12
UpToDate - Sugammadex: Drug Information}

Question 4

What dose of sugammadex should be administered to a patient with a moderate block (after appearance of second twitch on)?

Answer 4

• 2 mg/kg

_{Anesthesia Guidebook - Episode 18: Anesthesia Top Drawer Run Down - Part 2
Nagelhout (7th ed.), p. 176 - Table 12.12
UpToDate - Sugammadex: Drug Information}

Question 5

For immediate reversal of rocuronium induced blockade, what dose of sugammadex is administered?

Answer 5

• 16 mg/kg

_{Anesthesia Guidebook - Episode 18: Anesthesia Top Drawer Run Down - Part 2
Nagelhout (7th ed.), p. 176 - Table 12.12
UpToDate - Sugammadex: Drug Information}

Question 6

What is the onset of action of sugammadex?

Answer 6

• 1-2 minutes

_{Anesthesia Guidebook - Episode 18: Anesthesia Top Drawer Run Down - Part 2
Nagelhout (7th ed.), pp. 174 - Table 12.11; 176 - Table 12.12}