Sudden Death Science

Question 1

What are after depolarisations?

Answer 1

Abnormal depolarisations of cardiac myocytes that interrupt phase 2,3, or 4 of the cardiac AP in the cardiac condition system of the heart

Question 2

What can after depolarisations cause?

Answer 2

Triggered activity seen as sustained cardiac arrhythmias

Question 3

What are early after depolarisations EADs?

Answer 3

Abnormal depolarisation during phase 2 or phase 3 caused by an increase in the frequency of abortive APs before normal depolarisation is completed

Question 4

What does this SMAD4:p.Arg157Ile Tell you about the mutation?

Answer 4

The arginine in the peptide sequence of SMAD4 at position 157 has mutated to an Isoleucine

Question 5

What does this SMAD4:p.Cys162Ter Tell you about the mutation?

Answer 5

The cystine in the peptide sequence of SMAD4 at position 162 has mutated to a stop codon

Question 6

What does this SMAD4:c.2352A>T tell you about the mutation?

Answer 6

The adenine in position 2353 in the cDNA sequence has mutated to a thymine