Sudden Cardiac Death Flashcards
This is the condition where there is progressive heart failure due to ischemic myocardial damage.
Ischemic Heart Disease (IHD)
What is the usual causitive agent to IHD?
post-MI
Why are hearts big and heavy in IHD?
LV hypertrophy and dilation
What is usually found in the coronary arteries in IHD?
Atherosclerosis
This is the condition where there is unexpected death from cardiac causes in individuals without symptomatic heart disease or early after symptom onset.
Sudden Cardiac Death (SCD)
What is the main precursor to SCD?
IHD
What is the main direct cause of SCD?
Lethal arrhythmia (asystole, V fib)
What is the main cause of lethal arrhtynmias to cause SCD?
acute myocardial ischemia
Prognosis is improved in SCD patients when u implant what device?
defibrillator
What are the 9 nonatheroscletoic conditions associated SCD?
lol donno how to make a flaschard for this shit.
- Congenital structural or coronary arterial abnormalities
- Aortic valve stenosis
- Mitral valve prolapsed
- Myocarditis
- Dilated or hypertrophic cardiomyopathy
- Pulmonary hypertension
- Hereditary or acquired cardiac arrhythmias
- Cardiac hypertrophy of any causes (e.g., hypertension)
- Other (systemic metabolic & hemodynamic alterations, catecholamines, & drugs of abuse, particularly cocaine & methamphetamine)
Which inherited anatomic conditions are associated with SCD?
congential anomalies, hypertrophic cardiomyopathy, mitral valve prolapse
What is the main primary electrical disorder to SCD?
Long QT
What is the mutated gene to cause long QT syndrome?
KCNQ1
What is the main primary electrical disorder to SCD?
Long QT
What is the mutated gene to cause long QT syndrome?
KCNQ1
So atherosclerosis is big in SCD (obvi), so what % stenosis is usually present in one or more of the 3 major vessels?
75% (critical)
This genetic condition is characterized by replacement of portions of the RV with adipose and fibrous tissue from mutations in desmosomes.
Arrhythmogenic Right Ventricular Dysplasia (ARVD)
What will happen in V1-3 to the T waves in ARVD?
inversion
sometimes u see a little goofy epsilon wave in V1
What is the inherited disorder that is characterized by mutations in a sodium channel subunit gene SCN5A.
Brugada
This inherited condition is associated with prolonged ventricular depolarization and puts pts at risk for polymorphic ventricular tachycardia.
Long QT syndrome
What is the best treatment for Brugada syndrome?
ICD
This inherited condition is assocaited with prolonged ventricular depolarization and puts pts at risk for polymorphic ventricular tachycardia.
Long QT syndrome
These 2 common forms of LQT are associated with ventricular arrhythmias during physical exercise or emotional stress.
LQT1 and LQT2
When do patients with LQT3 likely experience episodes?
when resting or sleeping
Which class of drugs are used to reduce the risk of arrhythmias in many forms of LQTs?
B-blockers
This is the syndrome where there is ventricular tachycardia and/or V fib during exercise or emotional arousal (you make my heart race. and then u kill me).
Familial Catecholaminergic Polymophic VT
What causes FCPVT?
delayed afterdepolarizations
There are mutations in genes that handle which ion to cause FCPVT?
Ca++
