Substance Use Addictive Disorders Flashcards
tolerance vs dependence
tolerance: needing more and more to get same result
dependence: body needs substance to function normally
intoxication occurs at blood alc btwn?
100-200mg/dl
death can occur at rangin from?
400 to 700mg/dl
standard drink of beer
12 fl oz
standard drink of malt liquor
8-9 fl oz
standard drink wine
5 fl oz
standard drink of distilled spirits
1.5 fl oz
s/s of alc w/draw
Tremors, N/V, malaise or weakness, tachycardia, diaphoresis, elevated BP, anxiety, irritability, headache, insomnia, risk of seizure, and death
delirium
what is delirium tremens
s/s?
precautions and meds?
LOC change begins within 48-72 hours of last drink or heavy use.
Symptoms
Restlessness, coarse tremor, fear, confusion/ clouded sensorium, agitation, visual hallucinations, illusions, fever, sensory hyperactivity, sleeplessness, delirium, seizure
Life threatening
Medical intensive care admission required; CIWA-Ar/CAM-ICU (Confusion Assessment Method-ICU)
Calm environment
Seizure precautions
Lorazepam drip
Intubation
what does lorazepam do for alc w/draw
calms down neurons wanting alc
tx anxiety
prevent seizures
going to have tolerance
taper
sliding scale based on CIWA
vitamin replacement
Alcohol interferes with absorption of vitamins.
Increased excretion of vitamins by kidney
Deficient in thiamine and folic acid
Folic Acid
Produces and maintains new cells
Makes normal RBC and prevents anemia
Thiamine
PROTECTIVE OF NEURONS (nystagmus)
Carbohydrate metabolism
Central and peripheral nerve cell function
Prevent Wernicke-Korsakoff encephalopathy
opioid w/draw symptoms
Dysphoria
muscle aches
nausea/vomiting
lacrimation or rhinorrhea
pupillary dilation
piloerection
sweating
abdominal cramping
diarrhea
yawning
fever
insomnia
tx mild w/draw
acetaminophen, aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.
Plenty of fluids and rest are important.
loperamide can help with diarrhea, dicyclomine for abdominal cramping, and hydroxyzine may ease nausea.
tx severe w/draw
a combination of a milder opioid (buprenorphine) that does not produce many of the addictive effects of other opioids and an opioid blocker (naloxone). The opioid blocker works mostly in the stomach to prevent constipation. (Suboxone)
Clonidine can help reduce the intensity of withdrawal symptoms by 50-75%. Clonidine is especially effective at reducing anxiety, cramping, muscle aches, restlessness, sweating, tears, runny nose
Methadone: an opioid agonist
agonist v antagonist
agonist increases effects
antagonist blocks effects