Substance Abuse 1 Flashcards

1
Q

What is a drug?

A

Medicine or other substance which has a physiological effect when ingested or otherwise introduced into the body

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2
Q

Which group are most likely to misuse drugs?

A

Age 16-24

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3
Q

What percentage of people have alcohol dependence?

A

4%

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4
Q

What is a substance use disorder?

A

cluster of cognitive, behavioural, and physiological symptoms indicating that the individual continues using the substance despite significant substance-related problems

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5
Q

What is addiction?

A

Chronic, primary, neurobiological condition influenced by genetic, psychosocial and environmental factors

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6
Q

What are the risk factors for drug misuse and addiction?

A

Genetics- men more likely

Socioeconomic

Environmental:
Home, family, friends using drugs
Low-self esteem
Stress
Easy access to drugs
Peer pressure
Mental health problems
Early exposure
Physical and sexual abuse
Trauma
Homelessness

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7
Q

What are the steps in the addiction cycle for recreational drugs?

A

Acute reinforcement/social drug taking

Escalating, binging, compulsive use

Dependence

Withdrawal

Protracted withdrawal

Recovery?

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8
Q

What is the initiation and progression of drug use most associated with?

A

Initiation- social and environmental factors

Progression- neurobiological factors

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9
Q

What are the steps in the pattern of addiction for opioids?

A

Intense initial intoxication

Development of tolerance

Escalation in intake

Profound dysphoria, physical discomfort and somatic withdrawal signs during abstinence

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10
Q

What is the addiction pattern for alcohol?

A

Initial intoxication less than opiods

Binges

Severe emotional and somatic withdrawal syndrome

Intense craving for drug often driven by negative emotional states but also positive

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11
Q

What areas of the brain are associated with the reward pathway?

A

Ventral Tegmental Area

Nucleus Accumbens

Prefrontal cortex

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12
Q

What occurs in the reward pathway?

A

Activated by rewarding stimulus (food, water, sex)
-> information travels from the VTA then Nucleus accumbens then prefrontal cortex
-> dopamine mediated transmission allows feeling of pleasure

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13
Q

What are the effects of different neurotransmitters on how we feel?

A

Increased dopamine- euphoria

Increased serotonin- increased contentment

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14
Q

What are the elements in the psychodynamic theory of addiction?

A

2 critical
-> disordered emotions
-> disordered self- care

2 contributory
-> disordered self-esteem
-> disordered relationships

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15
Q

What happens upon chronic exposure to drugs?

A

Reduced sensitivity of brain to reward system

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16
Q

What is withdrawal?

A

Array of symptoms that follow sudden withdrawal of drug that patient had been physically dependent on

17
Q

What is tolerance?

A

Users become less sensitive to the effects of a drug and require larger doses to achieve same effect previously produced by lower doses

-> different for different drugs

18
Q

What are the different ways of classifying drugs?

A

Behavioural

Pharmacodynamic

Legal

19
Q

What are the different types of behavioural classifications for drugs?

A

Stimulants- cocaine, amphetamines, nicotine

Opioids- bind to opiod receptors and produce analgesia

Sedative hypnotics- decrease arousal and have anti-anxiety, hypnosis, sleep effect

Antipsychotics- Haloperidol

Antidepressants- SSRIs

Psychedelics- mind altering

20
Q

What are the different pharmacodynamic classifications of drugs? (describe effect on brain neurotransmission)

A

Stimulants- dopamine agonists

Opioids- opioid receptor agonists

Sedative hypnotics- directly/indirectly facilitate Y-aminobutryic acid

Antipsychotics- dopamine D2 receptor antagonists and serotonin 5-HT2 receptor antagonists

Antidepressants
- Serotonin/noradrenaline reuptake inhibitors

Psychedelics- facilitate serotonergic activity directly or indirectly increasing serotonin release

21
Q

What is an offence under the misuse of drugs act 1971?

A
  • to unlawfully possess a controlled drug
  • to possess a controlled drug with intent to supply it
  • to unlawfully supply (sell/give/share) a controlled drug
  • to allow premises you occupy or manage to be used for the smoking or use of drugs
22
Q

Which drugs are in different classes?

A

A (7 years)- cocaine, heroin, MDMA, LSD, methadone, crystal meth

B (5 years)- amphetamines, cannabis, codeine, ketamine

C (2 years in prison)- anabolic steroids, benzos, GHB

23
Q

What are the risks of illicit drug use?

A

Increased risk of infections
-> TB
-> STIs
-> IV drug use- BBVs

24
Q

What are the ways that recreational drugs are taken?

A
  • Oral – Alcohol, MDMA, Prescription Drugs
  • Transmucosal – Cocaine
  • Inhalation / Smoking - Cannabis
  • Intramuscular - Ketamine
  • Intravenous – Heroin
25
Q

What are some of the possible injection related complications?

A

Cellulitis

Abscess

Thrombophlebitis

Thrombosis

Embolism

DVT

Muscoskeletal infection

Endovascular issues

26
Q

What are the ways the BBVs can be transmitted?

A
  • Contaminated blood and blood products
  • Sharing of contaminated injecting equipment including needles, syringes, spoons, filters
  • Needle-stick injuries in health-care settings
  • Tattoos or piercing with contaminated equipment
  • Sharing of razors and toothbrushes in closed settings (HBV)
  • Mother-to-child transmission (MTCT) during pregnancy and delivery
  • Unprotected sex (HBV) , Rarely HCV
  • HCV is easily transmitted among individuals sharing injecting equipment
27
Q

What are the social implications of drug use?

A

Death

Suicides

Assaults

Drug related crime

Need for drug treatment services
-> fix room- supervised drug use (reduces public injecting, reduced needle sharing, improved uptake of addiction tx)

28
Q

What are some of the effects of cannabis?

A

Euphoria

Slowed thinking and rxn time

Confusion

Impaired coordination

Cough/resp infections

Impaired memory and learning

Anxiety and panic attacks

Tolerance

Addiction

29
Q

What issues could potential cause a fitness to practice meeting by GDC?

A
  • Behaviours involving or associated with potential criminality eg
  • dealing, possessing or misusing drugs/illegal substances even if there are no legal proceedings
  • Becoming involved in criminal activity
  • Violent behaviour
  • Abusive behaviour
  • Sexual harassment
  • Theft including shoplifting
  • Gaining a criminal conviction or caution
  • Financial fraud
30
Q

What do we recommend for alcohol intake?

A

14 units per week spread evenly over 3 days with alcohol free days (at least 2)

31
Q

What is the figure for daily alcohol misuse?

A

Exceeded 5 units

32
Q

What are the effects of alcohol?

A

CNS depressant

Impaired judgement, concentration, coordination

Aggression

Higher doses:
-> interference with cerebellar function
-> Ataxia
-> unconsciousness

33
Q

What are the RF for alcoholism?

A

Armed forced

Bachelors over 40

Bored housewives

Commercial travellers

Doctors

entertainers

Publicans in drinks industry

34
Q

What are the signs of addiction?

A

Loss of reliability

Mood changes

Impaired driving

Self-prescribing

Deteriorating attitude and behaviour

Personal/professional isolation

Wastage of drugs

Sloppy record keeping

35
Q

What are the causes of stress in students?

A

Dislocation from family

Relationships

Time demands of study

Finical issues

Lack of sleep

New environment

36
Q

What are the physical effects of stress?

A

Increased HR

Increased BP

Palpitation

Increase muscle tension- headaches, dizziness, jaw ache, insomnia

Sweating/blushing- hands and feet

37
Q

What are the mental effects of stress?

A

Small amounts- stimulation

Too much- affects thinking
-> confusion
-> focussing on worries
-> being preoccupied
-> negative thinking
-> difficulty making decisions

38
Q

What are the emotional effects of stress?

A

Irritability

Impatience

Anger

Frustration

Fear/anxiety

Self-doubt

Panic

Despondency

Feeling inadequate/insecure

Hopeless

Depression

39
Q

What should be done if you or colleague have addiction problem?

A

Put interests of patient first

Consult senior colleague and ask for advice/support
-> document encounter

Consider whether you are safe to practice

Engage with support groups and medical services