Subcutaneous and Systemic Flashcards
dark fungi that form melanin
Dematiaceous
specialized hyphal branch that produces successive conidia
Conidiophore
an open-ended, tubular or flask-like conidiophore that produces phialoconidia
Phialides
involve the dermis and subcutaneous tissue
Subcutaneous mycoses
often result from traumatic skin puncture
Subcutaneous Mycoses
Classification of Subcutaneous Mycoses
Chromoblastomycosis
Mycetoma
Phaeohyphomycosis
Sporotrichosis
General Characteristics of Subcutaneous Fungal Species
- dark color
- found in soil
- growth rate: 1-4 weeks
- septated hyphae
Mode of transmission of Subcutaneous Mycoses
acquired by mechanical means (trauma)
Fungal species of Chromoblastomycosis
Forsecaea species, Phialoph Verrucosa, Cladosporium carrionii, Exophiala jeanselmi
Fungal species of Mycetoma
Pseudoallescheria, Acremonium, Curvularia, Madurella
Classified to be a dimorphic fungi
Sporothrix schenkii
most commin isolated agent of Chromoblastomycosis
Forsecaea Pedrosoi
Fungal Species of Sporotrichosis
Sporothrix schenkii
Classification of Subcutaneous Mycoses
Chromoblastomycosis
Mycetoma
Phaeohyphomycosis
Sporotrichosis
flask or cup-shaped fungi
Phialophora verrucosa
Fungal species of Chromoblastomycosis
Fonsecaea pedrosoi
Phialophora verrucosa
Cladoporium carrionii
Exophiala jeanselmi
Fungal species of Phaeohyphomycosis
Bipolaris, Curvularia, E. jeanselmi, W. dermatitis
Fungal species of Mycetoma
Pseudoallesheria
Acremonium
Curvularua
Madurella
Fungal species of phaeohyphomycises
Bipolaris
Curvularia
Exophiala jeanselmi
W. dermatidis
Caused by dematiaceous fungi
Chromoblastomycosis
Fungal species of Sporotrichoses
Sporothrix schenkii
Classified as Dimorphic Fungi (Subcutaneous)
Sporothrix schenkii
Lesions of Chromoblastomycosis
Cauliflower-like lesions with secondary infection and ulceration
Most commonly isolated agent of Chromoblastomycosis
Forsecaea pedrosoi
Predominant form of Chromoblastomycosis
Dark, septated hyphae with primary conidia on tip
flask or cup-shaped fungi
Phialophora verrucosa
dome-shaped fungi
Phialophora verrucosa
looks like “wheat”/palay
Cladosporium carrioni
treatment of Chromoblastomycosis
no really good cure but it can be
Thiabendazole
or
Itraconazole
Tumor-like deformaties of subcutaneous tissue with abscesses draining sinuses and granulomatous pus
Mycetoma
2 types of mycetoma
Actinomycotic (Bacterial)
Eumycotic (Fungal)
results from infection with aerobic Actinomyces
Actinomycotic mycetoma
examples of Actinomycotic mycetoma
Nocardia, Actinomadura, streptomyces
associated with several fungi species that have septate hyphae
Eumycotic mycetoma
examples of Eumycotic mycetoma
Pseudoallescheria Aspergillus Exophiala Acremonium Curvularia Madurella
also known as Madura foot
Mycetoma
Mycetoma Triad of symptoms
Swelling, sinus tracks, sulfur granules
possess a one-celled conidia gathered at the tip of annelids
Exophiala jeanselmi
Sexual Pseudoallescheria
boydii
Asexual Pseudoalleschera
apiospermum
golden-brown, single celled conidia on tips of conidiospores
apiospermum
sac (ascus) containing ascospores
boydii
Agent of Pseudoallescheria
Pseudoallescheria boydii
causes opportunistic infections like meningitis, brain abscesses and arthritis
Pseudoallescheria boydii
infection may become invasive systemic and or cerebral
Phaeohyphomycosis
invading various organs
systemic
Most commonly isolated agent of phaeohyphomycosis
Wangiella dermatitidis
blast-shape conidiophore
Wangiella dermatitidis
Temperature requirement of Wangiella dermatitidis
grows well at 40 Deg Celsius
cause of Sporotrichosis
Sporothrix schenkii
“rose-thorn or rose-gardener’s disease”
Sporotrichosis
Mode of transmission of Sporotrichosis
acquired through skin pricking from the thorn of Rose plant
Treatment of Sporotrichosis
Potassium iodide solution
conidia arranged singly or in flowerette arrangement
Sporothrix schenkii
Temperature requirements of Sporothrix schenkii
Mycelial form: 25 Deg Celsius
Yeast form: 35-37 Deg Celsius
Culture of Sporothrix Schenkii
Rapidly grwoing
Starts light then turns dark
deep seated fungal infections caused by Dimorphic Fungi
Systemic Mycoses
also known as “North American Blastomycosis”, “Blastomycetic Dermatitis” or “GilChrist’s disease”
Blastomycosis
Endemic in areas south of Ohio River
Blastomycosis
Mode of transmission of Blastomycosis
acquired through inhalation of fungus from environment
incubation period of blastomycosis
30 to 100 days
Mycelial phase of Blastomyces dermatitidis
“lollipops”
Yeast Phase of Blastomyces dermatitidis
Thick-walled large yeast cells with single bud
creamy, waxy. and heapedye or wrinkled inhibited by chloramphenicol cycloheximide
yeast phase of Blastomyces dermititidis
waxy, yeast like becoming cottony
Mycelial phase of Blastomyces dermatitidis
another name for Coccidiodomycosis
“Valley Fever”, “California fever”, “Desert rheumatism” , “San Joaquin valley fever”
Most commonly isolated agent of Coccidiodomycosis
Coccidiodes immitis
endemic in U.S.
Coccidiodomycosis
mode of transmission of Coccidiodomycosis
inhalation of particles
how many days does the culture of Coccidiodes immitis grows?
5-14 days
Also known as “ Cave Disease “
Histoplasmosis
also known as “ Darling’s disease “
Histoplasmosis
Endemic on caves
Histoplasmosis
common among AIDS patients
Histoplasmosis
acquired through bird droppings and bats.. What bird?
Histoplasmosis
pigeon
can infect mucous membranes, lymphatics, skin
Paracoccidiodomycosis
another name for Paracoccidiodomycosis
“Brazilian Blastomycosis”
“ South American Blastomycosis”
Most often found in South and Central America and Mexico
Paracoccidiodomycosis
Paracoccidiodomycosis(mode of transmission)
- inhalation of spores
- chewing fungally contaminated food
mucocutaneous or cutaneous ulcers that spread to liver
Paracocidiodomycosis
treatment of paracoccidiodomycosis
Antifungal drugs
Yeast phase : Marimer’s or ship’s wheel (Multiple buds)
Paracoccidiodes brasiliensis
mycelial phase of Paracoccidiodes brasiliensis
Chlamydiospores
Culture: White leathery colony
Paracoccidiodes brasiliensis
3rd most common opportunistic infection in HIV patients
Penicilliosis
endemic in Southeast Asia
Penicilliosis
Temperature requirements of Penicillum marneffei
37 Deg Celsius - BHI blood
25 Deg Celsius -Sabouraud