Stuff to Memorize Flashcards
What’s the target of TLR-3?
Intra- or extracellular?
dsDNA
Intracellular
What’s the target of TLR-7 and TLR-8
Intra- or extracellular?
ssRNA
Intracellular
What’s the target of TLR-9?
Intra- or extracellular?
Demethylated CpG-rich DNA
Intracellular
What’s the target of TLR-5
Intra- or extracellular?
Flagella
Extracellular
What’s the target of dimerized TLR-1:TLR-2?
Intra- or extracellular?
Lipopeptides + GPI
Extracellular
What’s the target of dimerized TLR-2:TLR-6?
Intra- or extracellular?
Lipoteichoic acid
Extracellular
What’s the target of TLR-4?
Intra- or extracellular?
LPS
Extracellular
What’s the target of TLR-2?
Intra- or extracellular?
Bacterial peptidoglycan
Extracellular
Sources and actions of TNF
Macrophages, mast cells, T cells
Inflammation activation of endothelial cells (primarily).
Triggers expression of P and E selectins on endothelium to slow down neutrophils.
Neutrophil activation.
Sources and actions of IL-1
Macrophages, DCs, endothelial cells, mast cells
Primarily acts on hypothalamus to trigger fever.
Also acts on BM to stimulate WBC production.
Triggers expression on P and E selectins on endothelium to slow down neutrophils.
Sources and actions of IL-12
Macrophages, DCs
Increases IFN-γ production in NK and T cells.
Also triggers Th1 differentiation
Sources and actions of IL-6
Macrophages, endothelial cells, T cells
Stimulates B cells to differentiate into plasma cells
Sources and actions of IL-10
Macrophages, DCs, T cells
Leads to inhibition of cytokine production and decreased MHC II expression
Sources and actions of IL-15
Macrophages
NK and T cell proliferation
Sources and actions of IL-18
Macrophages
Acts on NK and T cells to increase production of IFN-γ (along with IL-12)
Sources and actions of IFN-α and -β
α - DCs and macrophages
β - Fibroblasts
Increases MHC I expression, NK cell activation, and puts cells into antiviral state (activation of RNAase, inhibition of protein synthesis, etc.)
Sources and actions of IFN-γ
NK and T cells
Activates macrophages
Sources and actions of TGF-β
Macrophages
Inhibition of inflammation, and differentiation of Th17 + Treg cells
Sources and actions of IL-7
Stromal cells of BM and thymus
First signal of lymphocyte production
Sources and actions of IL-23
Macrophages + DCs
Increase T cell proliferation and Th17 differentiation
CD for NK cells
16 and 56
CD for mast cells
23
CD for dendritic cells
80
CD for monocytes
14
CD for B cells
19 and 20
CD for T helper cells
3 and 4
CD for T cytotoxic cells
3 and 8
CD for T regulatory cells
3, 4, and 25
CD for neutrophils
15 and 16B
CD for B 1 cells
5
Cytokine secretion profile for Th1
IL-2, IFN-γ
Cytokine secretion profile for Th2
IL-4/5/13
Cytokine secretion profile for Th17
IL-17/22
Cytokine secretion profile for T regulatory cells
TGF-β, IL-10
