stuff i cant remember Flashcards
side effects of aluminum hydroxide? 4
constipation
hypophosphatemia
weakness, osteodystrophy
seizures/encephalopathy
SE of calcium carbonate? 3
hypercalcemia
rebound acid
calcium stones
SE of Mg hydroxide? 3
diarrhea
hyporeflexia
hypotension
contraindications for bismuth/sucralfate?
severe renal failure
antiplateletes/coags
absolute contras for bismuth?
GI bleeds salicylate hypersensitivity
what 5HT3 antiemetic si the worst cuase QT thing?
dolasetron
what 5HT3 has the longest half life so its good for CINV?
palonosetron
What occurs in serotonin syndrome?
neuromuscular hyperacitivy, agitation,
autonomic stimulation hyperthermia, diaphoresis, diarrhea
Best use for aprepitant?
post op
what H1 receptor agonist combo is good for prengant ladies with NV of P?
doxylamine + pyridoxine (b6)
what 3 antiemetics have anticholinergic SE?
H1 blockers
D2 blockers
M1 blocker
what are the 3 D2 antagonists that arent metoclopramide?
chlopromazine, perphenazine, prochlorperazine
what are the two weed drugs?
dronabinol
nabilone
whats youe 3 drug antiemetic regiment?
5ht3 + NK1 + roid
D2 next
Whats the black box warning for alostetron?
ischemic colitis
whats the dragons blood called and whats its MOA?
crofelemer
inhibits CFTR –> no cAMP –> blocks Cl channels
what are the constipation tx that arent laxatives?
guanylate cyclase C agonists
periph opiod antagoinst
selective chloride channel (C2) activators
what is the Guanylate cyclase C agonist learned? use? MOA?
linaclotide
IBS-c
activates GCC –> increases cGMP –> increases chloride thru CFTR
what are the peripheral opiod antagonists? 3
whats bad bout the 3rd?
methylnaltrexone
naloxegol
alvimopan –> MI risk
what os the selective chloride channel activator? MOA?
lubiprostone
activates CIC 2 channels –> more secretion
use for lubiprostone?
IBS-c
CIC
OIC
interactions with osmotic saline laxatives?
diuretics, CHF, HTN, renal disease
what are the non senna irritants?
bisacodyl
castor oil
glycerin
sodium picosulfate
what are bad things about irritants?
go into boob milk, GI obstruction/ileus
what is procolonoscopty only?
perpopik
what 4 drugs are UC?
5-ASA
JAK stat inhibitors
TNF-a inhibitors
4a-intigren inhibitors
what are the 4 5-ASA drugs?
-sala- mesalamine balsalazide osalazine sulfasalasizne
what is the JAK inhibitor?
tofacitinib
UC ONLY
what are the TNF-a inhibitors?
which are CD, UC, both?
adalimumab (both)
infliximab (both)
golimumab (UC)
certolizumab (CD)
SE of TNF-a inhibotrs?
liver toxicity, infecitons
what are the 2 a-4 integrin inhibitors? which is used for which
vedolizumab (BOTH)
natalizumab (CD)
whats the big side effect with natalizumab?
JC reactivation –> PML
whats the IL-12/23 inhibitor?
ustekinumab
what is fidaxomicin? MOA?
macrolide
binds and inhuibits 50s subunit
what is the MOA for iodoquinol?
halogenated hydroxyguinoline, unknown
MOA of nitazoxanide?
inhibits ferredoxin idioreductase
SE of nitazoxanide?
large salivary glands
yellow eyes and yellower pee
what is niclosamide used for? whats its MOA?
cestode fair
inhibitrs oxphos and ATPase activity
praziquantel MOA?
increases membrane permeability to Ca
what is the MOA of ledipasvir?
viral NS5A inhibitor –> virus cant replicated
HEP C
what is the MOA for ribavirin? contras?
inhibitrs synth of guanin nucleotides by inhibitirng monophosphate dehydrogenase
pregnancy, anemia
what is the MOA for simeprevir?
HCV protease inhibitor (NS35/4A inhibitor) –> no replication
what is the MOA for sofosbuvir?
inhibitrs HCV RNA dependant RNA polymerase (NS5B)
HEP C
when can you not use INF-a for hepatitis?
decompensated cirrhosis
what are the nucleoSIDES for hep B? 3
entecavir (1)
lamivudine
telbivudine
what are the nucleoTIDES for Hep B? 2
tenofovir (1)
adefovir
what are the other Hep C t protease inhibitors? that arent simeprevir
telaprevir
boceprevir
what are the other NS5A inhibitors that arent ledipasvir?
elbasvir
velpatasfvir
