stuff Flashcards
Crohns vs UC histopathology
Crohns- deep ulcers, increased Goblet cells, Granulomas, lymphocytes, full thickness/ transmural
UC - ulcers, pseudopolyps, decreased goblet cells, neutrophils, crypt abscesses, mucosa and submucosa only
UC acute mild/moderate
- definition
- tx
<6 stools/day (mild = <4)
systemically fine
- topical PR aminosalicylate (mesalazine, sulfasalazine)
- PR + PO aminosalicyclate
- PO aminosalicyclate and PO corticosteroid
UC acute severe
- definition
- tx
> 6 stools/day
systemically upset (inflam markers, anaemia, HR, Temp)
- IV steroids (admit!)
- IV ciclosporin
crohns/ UC barium enema
crohns: kantors string
UC: lead pipe
extensive UC acute tx
- PO +PR aminosalicyate (mesalazine, sulfasalazine)
- PO aminosalicylate + PO corticosteroid
UC mild/moderate maintenance
topical / oral (depending how extensive) aminosalicylate (mesalazine, sulfasalazine)
daily/intermittent
UC severe / 2+ relapses this year maintenance
PO azathioprine
crohns acute tx
- glucocorticoids
- aminosalicylate (sulfasalazine)
- azathioprine / mercatopurine
- infliximab
crohns maintenance tx
stop smoking
1. azathioprine / mercatopurine
2. surgery
adrenaline for cardiac arrest vs anaphylaxis
arrest - 1mg (every 3-5 mins for both shockable and non. shockable given after third shock, non right away)
anaphylaxis 0.5mg (adult, child 6-12y= 0.3, <6=0.15)
TB tx
- active
-latent
-meningeal
active
2m - rifampicin, isoniazid, Pyrazinamide, Ethambutol
4m- rifampicin, isoniazid
latent
3m rifampicin + isoniazid(+pyridoxine)
OR 6m isoniazid(+pyridoxine)
meningeal
12m minimum abx+ steroids
rifampicin s/e
hepatitis
enzyme inducer
orange secretions
flu-like
isoniazid s/e
hepatitis
enzyme inhibitor
peripheral neurtopathy
agranulocytosis
pyrazinamide s/e
hepatitis
gout , hyperuricaemia
myalgia
arthralgia
ethambutol s/e
optic neuritis