Study Guide Flashcards
Cancer prevalence in developing vs. the developed world
- Cancer is a leading cause of morbidity and mortality worldwide
- 70% of deaths occur in low- and middle-income countries with around ⅓ of deaths due to the
Opioid availability and which countries have met their opioid needs or have NOT met their opioid needs (only a few countries that have met or exceeded their opioid needs
Met: US
Unmet: Haiti, Nigeria, India/Indonesia, Russia, China, Uganda
Of these countries talk about how much of their opioid needs: be ready to rank countries based on their opioid availability (Nigeria, India, Uganda, Indonesia, Haiti, Australia, US, UK)
Ranking based on need Haiti (<1%) Nigeria (0.2%) India/Indonesia (4%) Russia (8%) Uganda (11%) China (16%)
Prevalence of cancer in developing words
Lower or higher
Lower
Prevalence of NCDs in the developing world
Lower or higher
Fewer NCDs (which are cancer risk)
Death rate in developing world
low or high
VERY HIGH death rates
Which has higher NCD’s developed or developing?
Developed world has higher NCDs (total) but developing world NCDs are growing at extremely high rates
Disparities in incidence of cancer and cancer survival: some places have lower incidence of cancer but higher death rates and vice versa. Have some idea of which continents have these types of disparities
Continents
- Africa
- SE Asia
- E Medit
Disparities in incidence of cancer and cancer survival: some places have lower incidence of cancer but higher death rates and vice versa. Have some idea of which countries have these types of disparities
COUNTRiES
- Libya (40%) to Norway (70%) for cervical cancer
- Jordan (16%) to USA (90%) for AML
Common barriers to opioid or morphine availability (4)
- Doctors get no palliative training
- Legislators or police oppose importation or make prescribing difficult
- “Opiophobia” - doctor unwillingness or fear to prescribe medication
- Pharma companies uninterested in marketing generic morphine (cheap=low profit)
Characteristics of oral morphine use
Diluting syrup with morphine so the concentration is not enough to get someone high or dependent but it effectively relieves pain
Can’t even get addicted to it if you take a lot
Structure of Uganda Morphine Program
- Who can administer
- Details of Program
Who can administer
Nurses with special training
Details of Program
AIDS patients had been dying screaming from cryptococcal meningitis or Kaposi’s sarcoma.
Allowed nurses with special training to prescribe morphine
Outside a private charity overseen by the government distributed oral morphine free of cost with two strengths. (0.5g or 5g per 500mL). This was so people who have to drink gallons to get high.
Risk factors for cancer in the developing world (10)
- HPV/Hepatitis/HIV (Communicable diseases)
- Tobacco/alcohol
- Obesity/Sedentary lifestyle
- Diet low in fruit/vegetables
- Occupational hazards
- UV exposure
- Urban air pollution
- Indoor smoke
- Cultural behaviors like skin bleaching
- Late presentation (caused by distrust)
Difference between the 2 components of early detection
Screening vs. Early detection
Screening
- Identifying individuals with abnormalities suggestive of a specific cancer or pre-cancer who have NOT yet developed symptoms and refer them for diagnosis/treatment.
- This is a more complex public health intervention compared to early diagnosis
Early detection
Programs designed to reduce delays/barriers to care to access treatment in a timely manner.
When is screening effective
when correct test are implemented effectively and are linked with other steps in the screening process.
Describe screening for cervical cancer in low-income areas
Visual inspection with acetic acid (VIA) for cervical cancer in low-income settings
Examples of screening
- Visual inspection with acetic acid (VIA) for cervical cancer in low-income settings
- HPV testing for cervical cancer
- PAP cytology test for cervical cancer in middle- and high-income settings
- Mammography screening for breast cancer in settings with strong or relatively strong health systems
Three steps that must be integrated and provided for early detection
Awareness and accessing care
Clinical evaluation, diagnosis, and staging
Access to treatment
T/F Early diagnosis means less morbidity, less expensive treatment, greater probability for surviving, and more likely to respond to effective treatments.
True
Early diagnosis means less morbidity, less expensive treatment, greater probability for surviving, and more likely to respond to effective treatments.
T/F
Early screening is not relevant in all setting and the majority of cancers.
False
Early screening is relevant in all setting and the majority of cancers.
What is the “See and Treat” approach for screening women,
4 benefits
An alternative which would screening women and simultaneously treating them if they have any abnormality
- Cheap and easy to operate equipment
- Specialist surgical skills not required
- Rare complications
- Women diagnosed with lesion are not lost to follow-up
Approaches to cervical cancer for high income (3)
- Pap smear for screening requires follow up and requires a skilled healthcare professional who knows how to evaluate results
- Surgical conistation for treatment that requires hospital admission
- Mammogram machines- high resource areas
Approaches to cervical cancer for low income (2)
- VIA (visual inspection with acetic acid)- use vinegar to identify normal cell spots→ doesn’t require follow up and treatment can be completed on the same day
- Loop cryotherapy for treatment- using a rod with liquid nitrogen to get rid of abnormal growths
Possible detection and screening protocols best suited for low-resourced setting
In low resource settings, use a “See and Treat” methodology→ screen, diagnose, and treat them at the same time since follow up may not be as feasible
Possible detection and screening protocols best suited for well-resourced vs. low-resources
Consider Pap Smear (High) vs. HPV vaccine (high)
VIA method (low resource) vs. contraception + education
What are the most important risk factors for cancer in the world
Tobacco
22% of cancer
Common symptoms for HIV and AIDS
- Cough
- Diarrhea
- Anorexia, Nausea, Vomiting
- Pruritus - dry skin, drug reactions, scabies, folliculitis
- Malaise, Weakness, Pyrexia
- Psychological Distress
What are the 4 ways that stigma manifests for people with HIV
- Physical Stigma - Isolated, shunned, neglected and forced to live apart because of violence
- Social Stigma - Voyeurism, social death, loss of standing in society
- Verbal Abuse - Gossip/taunting
- Institutionalized Stigma - Barred from jobs, scholarships, visas, health care, harassed by police
Burden of pediatric HIV now and the historic burden; compare current vs. past burden for kids with HIV
Current Burden: 160K in 2016
Historic Burden: 300K in 2010
Comparison: The burden is decreasing but still 400 children are infected every day due to
90% mother to child transmission, sexual abuse, child marriage, iv drug abuse, transfusions, unsterilized needles
Of the children infected with HIV whats the most common way
90% mother to child transmission
EC:
Another viral illness that is fatal that also requires significant palliative care when it occurs
Rabies - 100% fatal
Acute encephalomyelitis
Know 5 different types of paralysis
- Quadraplegia - affects all four limbs and trunk as result of spinal injury above the thoracic vertebra
- Paraplegia - affects the loss of movement in both legs from injury located below the thoracic vertebra
- Monoplegia - caused by spinal injury and affects just one limb
- Diplegia - affects symmetrical parts of the body normal both arms or two sides of the face
- Hemiplegia - affects only one side of the body (usually result of a stroke)
Quadraplegia
affects all four limbs and trunk as result of spinal injury above the thoracic vertebra
Paraplegia
- affects loss of movement in both legs from injurt located below the thoracic vertebra
Monoplegia
- caused by spinal injury and affects just one limb
Diplegia
- affects symmetrical parts of the body normal both arms or two sides of the face
Hemiplegia
- affects only one side of the body (usually result of a stroke)
Intrinsic risk factors for falls (11)
- Previous falls history
- Age
- Gender
- Living alone
- Polypharmacy
- Multiple comorbidities
- Impaired mobility
- Psychological status
- Nutritional deficiencies
- Cognition
- Visual impairments
Extrinsic risk factors for falls (6)
- Poor lighting
- Slippery floors
- Uneven surfaces
- Cluttered living spaces
- Inappropriate walking aid
- Poor footwear and clothing
Non-modifiable risk factors for falls
- Age
- Sex
Delirium vs. Dementia
Neuron status
Delirium - impaired neurons
Dementia - death of neurons
Delirium vs. Dementia
Onset
Delirium- acute and dramatic
Dementia - gradual and slow
Delirium vs. Dementia
Amnesia
Delirium - global amnesia/complete loss or orientation and short term memory
Dementia - selective amnesia - attention loss more in long term
Delirium vs. Dementia
Causes
Delirium - infectious, metabolic, toxic, trauma, respiratory
Dementia - idiopathic (alzheimer), residual
Delirium vs. Dementia
Misdiagnosis
Delirium - acute psychoses + agitated mania
Dementia - pseudo-dementia, diagnosed with dementia when its depression
Delirium vs. Dementia
Prognosis
Delirium - good if on time and (reversible)
Dementia - poor (irreversible)
Delirium vs. Dementia
Treatment
Delirium - treat cause of delirum
Dementia - cholineserase inhibitors
Describe Terri Schiavo
The media portrayed her case to be about assisted suicide when in reality she just wanted her feeding tube removed. In court, her parents advocated against removing her tube, while her husband pushed to keep it.