Studies general

Question 1

ADHERE

Answer 1

1. women with HF are older than men
2. Renal insufficiency has 50% increased relative mortality risk

Question 2

OPTIMIZE HF

Answer 2

African americans with AHF are younger, more reduced HF, hypertensive, with renal problem

Question 3

BNP

Answer 3

BNP for heart.failure is >100

Question 4

PRIDE

Answer 4

NT pro BNP for HF is >900

Question 5

ASCEND

Answer 5

Trop I is elevated in 90% of HF patients

Question 6

CARESS

Answer 6

Increasing diuretics is better than ultrafiltration in HF

Question 7

ALARM HF

Answer 7

Dopamine and dobutamine increase mortality by 1.5 and Norepinephrine and Epinephrine increase hospital mortality by 2.5/ Vasodilators and diuretics for AHF better in hospital survival

Question 8

ESCAPE

Answer 8

the use of PA catheter did not significantly affect the days alive and out of hospital

Question 9

DOSE

Answer 9

1. IV diuretics should be 1-2.5x the oral dose
2. No difference between furo bolus vs furo drip in symptoms or renal function

Question 10

CASINO

Answer 10

Increased mortality with dobutamine compared with placebo

Question 11

DAD HF

Answer 11

Low dose furosemide and dopamine comparable urine output and dyspnea relief

Question 12

EVEREST

Answer 12

Tolvaptan + standard treatment helped achieved modest relief

Question 13

UNLOAD

Answer 13

Ultrafiltration does not improve dyspnea or renal function but decreased re hospitalization

Question 14

FAIR HF

Answer 14

IV iron for IDA improves NYHA and global assessment

Question 15

RED HF

Answer 15

Darbepoitein for anemia in HF has no significant difference in primary outcome

Question 16

REF HF

Answer 16

Hemoglobin may be a prognostic marker in HF

Question 17

HF ACTION

Answer 17

Exercise training did not improve all cause mortality and hospitalization

Question 18

SOLVD SAVE TRACE

Answer 18

Acei reduces likelihood of hospitalization and being symptomatic in asymptomatic patients

Question 19

ROCKET AF

Answer 19

Population: East Asian patients with AF
i: Rivaroxaban vs Warfarin
Conclusion : Higher risk of bleeding for East asians
Rivaroxaban was associated with less critical bleeding, intracranial hemorrhage