Strong opioid agonists

Question 1

Strong opioid agonists - 8 drugs

Answer 1

Morphine
Fentanyl
Meperidine
Methadone 
Oxycodone
Sufentanil
Alfentanil
Remifentanil

Question 2

Strong opioid agonists - adm

Answer 2

Fentanyl - parenteral, transdermal, sublingual, buccal.
Meperidine, methadone and morphine - oral and parenteral.
Oxycodone - oral
Sufentanil - parenteral
Remifentanil - only IV infusion

Question 3

Long-acting strong opioid agonist

Answer 3

Methadone.

Question 4

Strong opioid agonists with active metabolites

Answer 4

Meperidine

Morphine

Question 5

Morphine - MOA

Answer 5

6-glucoronide metabolite is more active than morphine.

Question 6

Morphine - indications

Answer 6

Severe pain associated with trauma, MI, cancer.
Chronic pain.
Pain after major surgery.

Question 7

Derivatives of fentanyl - 3 drugs

Answer 7

Sufentanil
Alfentanil
Remifentanil

Question 8

Most potent opioid agonists

Answer 8

Fentanyl, sufentanil, alfentanil, remifentanil.

Question 9

Fentanyl and derivatives - indications

Answer 9

Severe or chronic pain.

Pre- and postoperative as adjunct to general anesthesia.

Question 10

Fentanyl - adverse effects

Answer 10

Truncal rigidity (when used as adjunct to parenteral anesthesia). 
Less nausea.

Question 11

Strong opioid agonist with ultra rapid onset of action

Answer 11

Remifentanil. Recovery within 5-10 min

Question 12

Strong opioid agonist with no antitussive effect

Answer 12

Meperidine

Question 13

Meperidine - indications

Answer 13

Obstetric or postsurgical analgesic (parenteral).
Moderate to severe pain (oral).
Short-term treatment of acute pain syndromes.

Question 14

Meperidine - adverse effects

Answer 14

Toxic metabolite (normeperidine): CNS excitation, convulsions, tremors

Question 15

Methadone - indications

Answer 15

Opioid dependence.

Chronic pain.

Question 16

Oxycodone - administration

Answer 16

Orally, usually with nonopioid analgesic.

Question 17

Oxycodone - indications

Answer 17

Moderate to severe pain