Stroke Drugs

Question 1

What are contraindications to using Dabigatran?

Answer 1

Phenytoin, Carbamazepine, PhenoBarb.

Question 2

How do you dose Dabigatran?

Answer 2

If 1 of the following:
Age > 80, concomitant treatment with verapamil
THEN: 110 mg BID

If 2 or more of the following: 
- age 75-80
- CrCl 30-49
-weight /= 3
THEN 110 mg BID

If none of the above, or one of the above,
Then, 150 mg BID

Question 3

What are contraindications to Rivaroxaban?

Answer 3

Cr Cl

Question 4

How do you dose Rivaroxaban?

Answer 4

If CrCl > 50, THEN 20 mg OD

If CrCl between 15- 50, 
and two or more:
- age>75
- weight / 3
- concomitant treatments 
THEN 15 mg OD

Question 5

How do you dose Apixaban?

Answer 5

• CrCl > 50 ml/min
• CrCl 30-50 ml/min and
  60 kg
  THEN 5 mg BID
• CrCL 15-29 ml/min
• 2 or more:
• – creatining >/133
• – Age > 80 years
• – weight

Question 6

What are contraindications to Apixaban use?

Answer 6

CrCl