Stroke and Movement Disorders Flashcards
What is the definition of a stroke?
Interruption of blood supply to an area of the brain, causing signs and symptoms of intracranial neurologic compromise.
What is a TIA?
Transient interruption of blood supply to an area of the brain causing symptoms lasting for under 24 hours
What % of strokes are ischemic and hemorrhagic?
85% ischemic
15% hemorrhagic
What is the most important nonmodifabile risk factor for strokes?
Age
What is the most important modifable risk factor for strokes?
HTN
What are some major risk factors for stroke?
HTN, smoking T2DM, HLD, CAD/CHF, Afib, carotid stenosis
What are the three types of ischemic strokes?
- embolic- sudden onset deficits
- thrombosis- gradual onset deficits, MC type of ischemic stroke
- lacunar (putamen, thalamus, internal capsule), variable onset, related to HTN
What is the most common type of ischemic stroke?
Thrombotic
Where is the classic location for SAH?
Berry aneurysm bursts at the anterior communicating artery (next most common Pcomm)
What is the classic presentation for SAH?
Sudden onset during exertion
“Worst headache of my life”
How does a posterior communicating artery aneurysm present?
CN III compression –> blown pupil, ptosis, down and out
What is the Hunt and Hess Scale?
Used to grade SAH 1 = roughly asymptomatic 2 = headache, neck stiffness 3 = headache, neck stiffness, confused 4 = completely unintelligible as if they are very drunk 5 = coma
higher score = increased acute mortality, but generally more favorable functional prognosis if they survive the acute period.
When do SAH occur vs intracerebral hemorrhages?
SAH = exertion intracerebral = at rest
What is the most common site of an intracerebral hemorrhage?
Putamen (contralateral hemiplegia)
What is the goal BP in ischemic strokes?
SBP <220
What is the goal BP in hemorrhagic strokes?
SBP <180
What is the goal ICP in the setting of a stroke?
Keep ICP < 20 mmHg
(Remember we want CPP to be >60mmHg)
CPP = MAP - ICP
What techniques can be used to lower ICP in patients with strokes?
Forced hyperventilation IV mannitol Elevate HOB Hypothermia (last resort) Neurosurgical Burr hole decompression
What are the considerations for tPA? (timeline, age, additional labs and imaging?)
Presenting within 3 hours of stroke onset
Adult (not elderly)
Negative CT head for blood
SBP <185
INR <1.7
Platelets <100k
Stroke territory involves <1/3 MCA territory
What are considerations for SAH and intracerebral hemorrhage management? (blood pressure, ICP, medications, treatment)
Keep SBP <180
Stool soft –> docusate, miralax
Keep ICP <20
Nimodipine x21 days to prevent secondary intracranial vasospasm due to blood irritating vessels
Perform clipping/coiling of aneurysm or removing the AVM
How long does an infarction typically take to show up on a CTH? What color is blood on CT? What color is infarction?
1-2 days usually
Blood = white
Infarction = dark area
(Opposite of T2 MRI)
What color is blood on T2 MRI? What color is infarction?
Blood = dark
Infarction = bright white on T2 MRI (T2 = H2O)
(Opposite of CT)
What is the purpose of getting an echo for a stroke workup?
Look for:
Cardiac embolus source
Wall motion abnormalities
PFO
What is the purpose of getting an LP in the setting of possibles troke?
Helpful when CT head is not informative but you still suspect SAH
Xanthochromia (blood breakdown products) can be detected indicating SAH
What is the purpose of carotid artery US in the setting of possible stroke?
Helpful looking for carotid stenosis
What is secondary prevention for strokes?
Preventing strokes after at least one has occurred
What anticoagulation, antiplatelet therapy would you use for the following:
Cardioembolic stroke
Warfarin (goal INR 2-3)
OR
NoAC (rivaroxaban, apixaban, dabigatran)
What anticoagulation, antiplatelet therapy would you use for the following:
Thrombotic stroke
ASA 81mg
What anticoagulation, antiplatelet therapy would you use for the following:
Carotid stenosis
ASA + dipyridamole
If carotid stenosis >70% and symptomatic, what would be the next step in managment?
Carotid endarterectomy (CEA)
Prognostically, when will most of the recovery of a stroke occur?
Within the first 3-6 months
Motor, speech, swallow, bowel, bladder
Anterior cerebral artery primarily supplies which muscles?
Leg muscles (also executive function)
Middle cerebral artery primarily supplies which muscles?
Face and upper extremity muscles
also language and spatial perception
Anterior cerebral artery primarily supplies the brain to perform which cortical functions?
Executive functions
Middle cerebral artery primarily supplies the brain to perform which cortical functions?
Language and spatial perception
Posterior cerebral artery primarily supplies which areas of the brain?
Cerebellar and visual cortices
Walk through the flow of CSF from the choroid plexus to the subarchanoid space.
Choroid plexus Lateral ventricles Foramina of Monro Third ventricle Cerebral aqueduct Fourth ventricle Foramen of Magendie Foramina of Luschka Subarachnoid space
What are the 4 midline structures in the rule of 4s?
Midline startswith M
- Motor pathway
- Medial lemniscus
- Medial longitudinal fasciculus
- Motor nuclei
What are the 4 side structures in the rule of 4s?
Side starts with S
- Spinothalamic pathway
- Spinocerebellar pathway
- Sensory nucleus of CN V
- Sympathetic
Which cranial nerve nuclei are NOT in the brainstem?
CN I and II
Which cranial nerve nuclei are located in the midline?
CN III, IV, VI, XII (divisible by 12)
What are the classic symptoms of an ACA stroke?
- Contralateral leg weakness and numbness (distal > proximal)
- Incontinence
- If bilateral: B/l symptoms and executive function with personality deficits
What are the classic symptoms of an MCA stroke?
- Contralateral face, arm, hand weakness and numbness
- Aphasia (dominant)
- Contralateral hemineglect (nondominant)
MCA stroke of the superior division of dominant MCA presents with which classic cortical deficit?
Broca aphasia (expressive aphasia)
MCA stroke of the inferior division of dominant MCA presents with which classic cortical deficit?
Wernicke aphasia (receptive aphasia)
MCA stroke of the inferior division of nondominant MCA presents with which classic cortical deficit?
Contralateral Hemineglect
Which type of aphasia?
Fluent, comprehension intact, repetition intact, cannot name things
Anomia
Which type of aphasia?
Nonfluent, comprehension intact, cannot repeat
Broca’s Aphasia
Which type of aphasia?
Nonfluent, comprehension intact, repetition intact
Transcortical motor aphasia
Which type of aphasia?
Fluent, cannot comprehend, cannot repeat
Wernicke’s Aphasia
Which type of aphasia?
Fluent, cannot comprehend, repetition intact
Transcortical sensory aphasia
Which type of aphasia?
Nonfluent, cannot comprehend, repetition intact
Mixed transcortical aphasia
Which type of aphasia?
Fluent, comprehension intact, cannot repeat
Conduction aphasia